Strain field measurements on mouse carotid arteries using microscopic three-dimensional digital image correlation

A stereomicroscope system is adapted to make accurate, quantitative displacement, and strain field measurements with microscale spatial resolution and nanoscale displacement resolution on mouse carotid arteries. To perform accurate and reliable calibration for these systems, a two‐step calibration p...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2008-01, Vol.84A (1), p.178-190
Main Authors: Sutton, M.A., Ke, X., Lessner, S.M., Goldbach, M., Yost, M., Zhao, F., Schreier, H.W.
Format: Article
Language:English
Subjects:
3D-digital image correlation
Animals
biomechanics
Calibration
Carotid Arteries - cytology
Imaging, Three-Dimensional - instrumentation
Imaging, Three-Dimensional - methods
Mice
Mice, Inbred C57BL
mouse carotid artery
noncontacting measurement
pressurization
stereocalibration
stereomicroscope
Surface Properties
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Description
Summary:A stereomicroscope system is adapted to make accurate, quantitative displacement, and strain field measurements with microscale spatial resolution and nanoscale displacement resolution on mouse carotid arteries. To perform accurate and reliable calibration for these systems, a two‐step calibration process is proposed and demonstrated using a modification to recently published procedures. Experimental results demonstrate that the microscope system with three‐dimensional digital image correlation (3D‐DIC) successfully measures the full 3D displacement and surface strain fields at the microscale during pressure cycling of 0.40‐mm‐diameter mouse arteries, confirming that the technique can be used to quantify changes in local biomechanical response which may result from variations in extracellular matrix composition, with the goal of quantifying properties of the vessel. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.31268