Endothelin-1 and bronchial hyperresponsiveness in the rabbit

Endothelins (ETs) are a family of peptide mediators that have a number of biological properties, including the ability to act as potent bronchoconstrictors of isolated human airways. Moreover, elevated concentrations of ET-1 in the bronchoalveolar lavage fluid from patients with symptomatic asthma h...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1998-11, Vol.358 (5), p.561-566
Main Authors: D'Agostino, B, Filippelli, A, Falciani, M, Rossi, F
Format: Article
Language:English
Subjects:
Airway Resistance - drug effects
Animals
Bronchial Hyperreactivity - etiology
Bronchial Hyperreactivity - physiopathology
Bronchoalveolar Lavage
Bronchoalveolar Lavage Fluid - cytology
Capsaicin - pharmacology
Dose-Response Relationship, Drug
Endothelin-1 - adverse effects
Endothelin-1 - pharmacology
Eosinophils - cytology
Eosinophils - drug effects
Female
Histamine - pharmacology
Leukocyte Count - drug effects
Leukocytes, Mononuclear - cytology
Leukocytes, Mononuclear - drug effects
Lung - drug effects
Lung - physiology
Lung - physiopathology
Male
Neutrophils - cytology
Neutrophils - drug effects
Rabbits
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Summary:Endothelins (ETs) are a family of peptide mediators that have a number of biological properties, including the ability to act as potent bronchoconstrictors of isolated human airways. Moreover, elevated concentrations of ET-1 in the bronchoalveolar lavage fluid from patients with symptomatic asthma have also been detected. We investigated the possible contribution of ET-1 in the development of bronchial hyperresponsiveness and the role of inflammatory cell accumulation in rabbit lungs. Our data show that ET-1 challenge to rabbits does not modify basal lung function but results in an increased airway responsiveness to inhaled histamine. Endothelin-treated rabbits were 3-fold (P
ISSN:0028-1298
DOI:10.1007/PL00005293