Clinicopathological study of invasive ductal carcinoma with large central acellular zone: Special reference to magnetic resonance imaging findings

Invasive ductal carcinoma (IDC) with central acellular zone is sometimes encountered, but its clinicopathological features have not yet been fully investigated. The clinicopathological features of 10 resected cases of IDC with a large central acellular zone were investigated. The tumor size ranged f...

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Published in:Pathology international 2008-01, Vol.58 (1), p.26-30
Main Authors: Yamaguchi, Rin, Furusawa, Hidemi, Nakahara, Hiroshi, Inomata, Masuko, Namba, Kiyoshi, Tanaka, Maki, Ohkuma, Kazuaki, Tayama, Kohsuke, Fujii, Teruhiko, Yano, Hirohisa, Kage, Masayoshi, Kojiro, Masamichi
Format: Article
Language:English
Subjects:
acellular zones
Adult
Aged
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma, Ductal, Breast - metabolism
Carcinoma, Ductal, Breast - pathology
Contrast Media
Female
Humans
Image Enhancement
Immunohistochemistry
invasive breast carcinoma
Ki-67 Antigen - metabolism
Magnetic Resonance Imaging
Middle Aged
MRI
Tumor Suppressor Protein p53 - metabolism
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Summary:Invasive ductal carcinoma (IDC) with central acellular zone is sometimes encountered, but its clinicopathological features have not yet been fully investigated. The clinicopathological features of 10 resected cases of IDC with a large central acellular zone were investigated. The tumor size ranged from 6 to 28 mm with a mean of 14.3 ± 6.9 mm. Contrast‐enhanced magnetic resonance imaging (MRI) showed a ring‐like appearance in the tumor. Sagittal fat‐suppressed T2‐weighted MRI had very high to intermediate signal intensity in a central area. Histologically, cancer tissue was located in the periphery of the tumor with a ring‐like pattern and a large central area was occupied by acellular amorphous tissue that was strongly stained by alcian blue. Lymph vessel permeation was seen in eight cases. Among the tumors with focal enhancement in the central areas >1 cm in diameter on contrast MRI, marked increase of microvessel was observed in the enhanced spot. The mean of p53 and Ki‐67 labeling indices was 56.2% and 36.3%, respectively. IDC with a large central acellular zone presenting with characteristic MRI should be noted as a new morphological entity.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2007.02184.x