MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

Abstract The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, an...

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Published in:Neurobiology of aging 2008-01, Vol.29 (1), p.31-38
Main Authors: Tapiola, Tero, Pennanen, Corina, Tapiola, Mia, Tervo, Susanna, Kivipelto, Miia, Hänninen, Tuomo, Pihlajamäki, Maija, Laakso, Mikko P, Hallikainen, Merja, Hämäläinen, Anne, Vanhanen, Matti, Helkala, Eeva-Liisa, Vanninen, Ritva, Nissinen, Aulikki, Rossi, Roberta, Frisoni, Giovanni B, Soininen, Hilkka
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer's disease
Analysis of Variance
APOE
Apolipoproteins E - genetics
Cognition Disorders - genetics
Cognition Disorders - pathology
Entorhinal cortex
Entorhinal Cortex - pathology
Female
Follow-Up Studies
Follow-up study
Hippocampus
Hippocampus - pathology
Humans
Internal Medicine
Magnetic Resonance Imaging - methods
Male
Memory
Middle Aged
Mild cognitive impairment
MRI
Neurology
Proportional Hazards Models
Volumetry
White matter lesions
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Summary:Abstract The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients had progressed to dementia (9 to Alzheimer's disease (AD)). In Cox regression analysis the baseline volumes of the right hippocampus, the right entorhinal cortex and CDR sum of boxes predicted the progression of MCI to dementia during the follow-up. In a bivariate analysis, only the baseline volumes of entorhinal cortex predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2006.09.007