Development of HIV encephalitis in AIDS and TNF-α regulatory elements

Tumor necrosis factor-α (TNF-α) appears to play an important role in HIV encephalitis (HIVE). TNF2, a polymorphism of TNF-α, associates with higher levels of TNF-α and severe manifestations of some infections. We studied 44 acquired immunodeficiency syndrome (AIDS) patients with autopsy-proven HIVE...

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Bibliographic Details
Published in:Journal of neuroimmunology 1998-11, Vol.91 (1), p.89-92
Main Authors: Sato-Matsumura, Kazuko C, Berger, Johannes, Hainfellner, Johannes A, Mazal, Peter, Budka, Herbert
Format: Article
Language:English
Subjects:
Acquired immunodeficiency syndrome (AIDS)
AIDS Dementia Complex - immunology
AIDS/HIV
Alleles
Antibodies, Viral - immunology
Brain - immunology
Brain - virology
Encephalitis
Encephalitis, Viral - immunology
HIV
HLA-DR3 Antigen - analysis
Human immunodeficiency virus
Human immunodeficiency virus (HIV)
Humans
Polymorphism, Genetic
Tumor necrosis factor alpha
Tumor Necrosis Factor-alpha - immunology
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Summary:Tumor necrosis factor-α (TNF-α) appears to play an important role in HIV encephalitis (HIVE). TNF2, a polymorphism of TNF-α, associates with higher levels of TNF-α and severe manifestations of some infections. We studied 44 acquired immunodeficiency syndrome (AIDS) patients with autopsy-proven HIVE and/or HIV leukoencephalopathy (HIVLE) (HIVE/LE) and 30 AIDS patients without HIVE/LE. TNF2 did not associate with presence of HIVE/LE ( p>0.5). Moreover, the TNF-α regulatory element TTATTTAT within the 3′-untranslated region was intact in HIVE/LE brains, and HLA-DR3 did not associate with HIVE/LE. Other host factors or, more likely, viral factors may be responsible for the development of HIVE/LE.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(98)00161-1