Bilateral mixed epithelial stromal tumor in an end-stage renal disease patient: the first case report

• Published in: Human pathology 2008, Vol.39 (1), p.142-146
• Main Authors: Sangoi, Ankur R., MD, Higgins, John P., MD
• Format: Article
• Language: English
• Subjects: Adult; Bilateral; Biological and medical sciences; Cystic nephroma; Cysts; Disease; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Kidney; Kidney Failure, Chronic - complications; Kidney Neoplasms - complications; Kidney Neoplasms - diagnosis; Kidney Neoplasms - metabolism; Kidney Neoplasms - pathology; Medical sciences; Mixed epithelial stromal tumor; Neoplasms, Complex and Mixed - complications; Neoplasms, Complex and Mixed - diagnosis; Neoplasms, Complex and Mixed - metabolism; Neoplasms, Complex and Mixed - pathology; Neoplasms, Second Primary; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Renal epithelial stromal tumor; Renal failure; Smooth muscle; Tumors; Women
• ISSN: 0046-8177; 1532-8392
• DOI: 10.1016/j.humpath.2007.08.001

Summary Although first intimated in the 1970s, mixed epithelial stromal tumor has been recognized as a diagnostic entity for less than 10 years, with an identity that has been challenged by overlap between other cystic renal neoplasms, most notably with cystic nephroma. We report the first case of a bilateral mixed epithelial stromal tumor occurring in a 41-year-old dialysis-dependent woman, notably also the first case reported in a patient with end-stage renal disease. The neoplasms occurred 5 years apart and were diagnosed as mixed epithelial stromal tumor in both instances. We describe the presentation and pertinent radiologic, histologic, and immunophenotypic findings of these neoplasms with a review of the current debate regarding mixed epithelial stromal tumor and cystic nephroma taxonomy.