ASEXUAL GROWTH OF BABESIA BOVIS IS INHIBITED BY SPECIFIC SULFATED GLYCOCONJUGATES

In the present study, inhibitory effects of several sulfated and nonsulfated glycoconjugates were evaluated on the in vitro asexual growth of Babesia bovis. Among the selected sulfated glycoconjugates, dextran sulfate, heparin, heparan sulfate, fucoidan, and chondroitin sulfate B strongly inhibited...

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Bibliographic Details
Published in:The Journal of parasitology 2007-12, Vol.93 (6), p.1501-1504
Main Authors: Bork, Sabine, Yokoyama, Naoaki, Hashiba, Shintaro, Nakamura, Kazuya, Takabatake, Noriyuki, Okamura, Masashi, Ikehara, Yuzuru, Igarashi, Ikuo
Format: Article
Language:English
Subjects:
Adhesives
Animals
Antiprotozoal Agents - pharmacology
Babesia bovis
Babesia bovis - drug effects
Babesia bovis - growth & development
Babesiosis
Biological and medical sciences
Cattle
Chondroitin sulfate
Dextran
Dextran sulfate
Dextran Sulfate - pharmacology
Dextrans
Dextrans - pharmacology
Erythrocytes
Experiments
Fucoidan
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Glycoconjugates
Glycoconjugates - chemistry
Glycoconjugates - pharmacology
growth and development
Heparan sulfate
Heparin
Hyaluronic acid
in vitro culture
inhibitors
Invertebrates
Keratan sulfate
Ligands
Merozoites
Molecular interactions
Parasite hosts
Parasites
Parasitology
Protamine sulfate
Sulfates
Sulfates - metabolism
Sulfates - pharmacology
THERAPEUTICS-DIAGNOSTICS
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Summary:In the present study, inhibitory effects of several sulfated and nonsulfated glycoconjugates were evaluated on the in vitro asexual growth of Babesia bovis. Among the selected sulfated glycoconjugates, dextran sulfate, heparin, heparan sulfate, fucoidan, and chondroitin sulfate B strongly inhibited the parasitic growth, and all but chondroitin sulfate B induced a significant accumulation of extracellular merozoites in culture. In contrast, chondroitin sulfate A, keratan sulfate, and protamine sulfate, as well as nonsulfated dextran and hyaluronic acid, did not influence the growth. These findings indicate that the asexual growth of B. bovis merozoites is inhibited by specific sulfated glycoconjugates, possibly providing us with an important insight into the molecular interaction(or interactions) during the process of the erythrocyte invasion by B. bovis merozoites.
ISSN:0022-3395
1937-2345
DOI:10.1645/GE-1166.1