B-Cell Tolerance Checkpoints in Healthy Humans and Patients with Systemic Lupus Erythematosus

: Antibodies are protective effector molecules in the body's immune defense against pathogens. However, if directed against the body's own tissues or organs, antibodies can also play a role in the pathogenesis of autoimmune disease. Here, we discuss our data on how autoreactive antibodies...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-12, Vol.1062 (1), p.165-174
Main Authors: YURASOV, SERGEY, HAMMERSEN, JOHANNA, TILLER, THOMAS, TSUIJI, MAKOTO, WARDEMANN, HEDDA
Format: Article
Language:English
Subjects:
autoantibody
autoimmunity
B cell
B-Lymphocyte Subsets - immunology
Case-Control Studies
Humans
Lupus Erythematosus, Systemic - immunology
Self Tolerance - immunology
SLE
tolerance
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Summary:: Antibodies are protective effector molecules in the body's immune defense against pathogens. However, if directed against the body's own tissues or organs, antibodies can also play a role in the pathogenesis of autoimmune disease. Here, we discuss our data on how autoreactive antibodies are regulated in healthy humans and how a failure to establish self‐tolerance during early B‐cell development in patients with systemic lupus erythematosus may predispose to the development of this autoimmune disease.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1358.019