Effect of antenatal hypoxia on age-specific dynamics of ECG parameters and content of biogenic amines in the central nervous system

We studied the effect of acute antenatal hypoxia during the stages of progestation and early organogenesis on some ECG parameters and level of biogenic amines in brain structures in rats. The effect of acute hypoxic exposure during the organogenesis period on the studied parameters was more pronounc...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2007-08, Vol.144 (2), p.188-191
Main Authors: Graf, A V, Maslova, M V, Trofimova, L K, Dunaeva, T Yu, Sokolova, N A, Kudryashova, N Yu, Krushinskaya, Ya V, Goncharenko, E N
Format: Article
Language:English
Subjects:
Age Factors
Animals
Autonomic Nervous System - physiopathology
Biogenic Amines - metabolism
Brain Stem - metabolism
Central Nervous System - metabolism
Cerebral Cortex - metabolism
Dopamine - metabolism
Electrocardiography
Female
Fetal Hypoxia - metabolism
Fetal Hypoxia - physiopathology
Heart - physiopathology
Male
Norepinephrine - metabolism
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Prenatal Exposure Delayed Effects - physiopathology
Rats
Serotonin - metabolism
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Summary:We studied the effect of acute antenatal hypoxia during the stages of progestation and early organogenesis on some ECG parameters and level of biogenic amines in brain structures in rats. The effect of acute hypoxic exposure during the organogenesis period on the studied parameters was more pronounced than the effect of acute hypoxic exposure during the progestation period. The shift of the autonomic balance towards the sympathetic regulation of cardiac activity is linked with increased content of biogenic amines in the brain stem and cortical structures.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0286-5