Effect of chemotype on Escherichia coli interactions with bactericidal proteins

We studied the effects of bactericidal proteins (lysozyme and lactoferrin) on endotoxin release from cell wall and inhibition of the growth of Escherichia coli colonies of different chemotypes. The structure of LPS core was found to be essential for the mechanisms of the interactions of the studied...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2007-08, Vol.144 (2), p.224-226
Main Authors: Zubova, S V, Grachev, S V, Prokhorenko, I R
Format: Article
Language:English
Subjects:
Animals
Blood Bactericidal Activity
Cattle
Cell Wall - chemistry
Cell Wall - drug effects
Chickens
Endotoxins - chemistry
Escherichia coli
Escherichia coli - classification
Escherichia coli - drug effects
Escherichia coli - pathogenicity
Escherichia coli - physiology
Lactoferrin - pharmacology
Lipopolysaccharides - chemistry
Muramidase - pharmacology
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Summary:We studied the effects of bactericidal proteins (lysozyme and lactoferrin) on endotoxin release from cell wall and inhibition of the growth of Escherichia coli colonies of different chemotypes. The structure of LPS core was found to be essential for the mechanisms of the interactions of the studied proteins with the cell wall. Cell viability after contact with cationic proteins is determined not by the amount of released LPS, but by the mechanism of damage to the cell wall.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-007-0295-4