Serological similarities between hyperreactive malarial splenomegaly and splenic lymphoma in West Africa

In West Africa hyperreactive malarial splenomegaly (HMS) and splenic lymphoma with villous lymphocytes (SLVL) are demographically and clinically indistinguishable. Determination of lymphocyte clonality is needed to differentiate clearly between these 2 disorders. To obtain evidence to support our hy...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 1998-07, Vol.92 (4), p.463-467
Main Authors: Wallace, S., Bedu-Addo, G., Rutherford, T.R., Bates, I.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antibodies, Protozoan - immunology
Biological and medical sciences
Diagnosis, Differential
Female
Ghana
Human protozoal diseases
Humans
hyperreactive malarial splenomegaly
Immunoglobulin M - analysis
Infectious diseases
Lymphoma, B-Cell - diagnosis
Malaria
Malaria, Falciparum - diagnosis
Malaria, Falciparum - immunology
Male
Medical sciences
Middle Aged
Parasitic diseases
Plasmodium falciparum
Plasmodium falciparum - isolation & purification
Protozoal diseases
Splenic Diseases - diagnosis
splenic lymphoma with villous lymphocytes
Splenomegaly - diagnosis
Splenomegaly - immunology
Tropical medicine
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Summary:In West Africa hyperreactive malarial splenomegaly (HMS) and splenic lymphoma with villous lymphocytes (SLVL) are demographically and clinically indistinguishable. Determination of lymphocyte clonality is needed to differentiate clearly between these 2 disorders. To obtain evidence to support our hypothesis that HMS and SLVL are aetiologically related we studied the serological profile of malaria-related antibodies in HMS and SLVL in West Africa. We found that in SLVL total immunoglobulin M and antimalarial antibody levels were markedly raised, a combination which is characteristic of HMS. These findings strongly support a developmental relationship between HMS and SLVL in tropical Africa and implicate malaria in this process.
ISSN:0035-9203
1878-3503
DOI:10.1016/S0035-9203(98)91095-1