Analysis of epitope spreading over an eleven-year period in a patient with Systemic Lupus Erythematosus

During a period of more than eleven years serum samples of a patient with Systemic Lupus Erythematosus were collected and analyzed for anti-nuclear autoantibodies. High titer of anti-La/SS-B were detectable in all serum samples. The La/SS-B epitopes remained constant. Besides anti-La/SS-B antibodies...

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Bibliographic Details
Published in:Scandinavian journal of rheumatology 1998, Vol.27 (6), p.461-464
Main Authors: ORTH, T, MAYET, W.-J, DEISTER, H, SOOGHEE CHANG, SCHMITZ, M, BACHMANN, M
Format: Article
Language:English
Subjects:
Adult
Antibodies, Antinuclear - analysis
Antibodies, Antinuclear - immunology
Biological and medical sciences
Epitope Mapping
Epitopes - immunology
Female
Humans
Lupus Erythematosus, Systemic - immunology
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:During a period of more than eleven years serum samples of a patient with Systemic Lupus Erythematosus were collected and analyzed for anti-nuclear autoantibodies. High titer of anti-La/SS-B were detectable in all serum samples. The La/SS-B epitopes remained constant. Besides anti-La/SS-B antibodies all serum samples contained traces of anti-Ro/SS-A including anti-Ro52 and anti-Ro60 antibodies. During disease flares anti-Ro/SS A antibodies were upregulated and anti-dsDNA antibodies appeared, thus supporting the concept of an antigen driven intermolecular epitope spreading to Ro/SS-A and dsDNA.
ISSN:0300-9742
1502-7732
DOI:10.1080/030097498442316