Osteotransductive bone cements

Abstract Calcium phosphate bone cements (CPBCs) are osteotransductive, i.e. after implantation in bone they are transformed into new bone tissue. Furthermore, due to the fact that they are mouldable, their osteointegration is immediate. Their chemistry has been established previously. Some CPBCs con...

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Bibliographic Details
Published in:Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine Journal of engineering in medicine, 1998-01, Vol.212 (6), p.427-435
Main Authors: Driessens, F C M, Planell, J A, Boltong, M G, Khairoun, I, Ginebra, M P
Format: Article
Language:English
Subjects:
Biomechanical Phenomena
Bone Cements - chemistry
Calcium compounds
Calcium Phosphates - chemistry
Ceramic materials
Chemical reactions
Drug Carriers
Gels
Gypsum
Humans
Materials Testing
Osseointegration - physiology
Phosphates
Rheology
Solutions
Strength of materials
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Summary:Abstract Calcium phosphate bone cements (CPBCs) are osteotransductive, i.e. after implantation in bone they are transformed into new bone tissue. Furthermore, due to the fact that they are mouldable, their osteointegration is immediate. Their chemistry has been established previously. Some CPBCs contain amorphous calcium phosphate (ACP) and set by a sol-gel transition. The others are crystalline and can give as the reaction product dicalcium phosphate dihydrate (DCPD), calcium-deficient hydroxyapatite (CDHA), carbonated apatite (CA) or hydroxyapatite (HA). Mixed-type gypsum-DCPD cements are also described. In vivo rates of osteotransduction vary as follows: gypsum-DCPD > DCPD > CDHA ≍ CA > HA. The osteotransduction of CDHA-type cements may be increased by adding dicalcium phosphate anhydrous (DCP) and/or CaCO3 to the cement powder. CPBCs can be used for healing of bone defects, bone augmentation and bone reconstruction. Incorporation of drugs like antibiotics and bone morphogenetic protein is envisaged. Load-bearing applications are allowed for CDHA-type, CA-type and HA-type CPBCs as they have a higher compressive strength than human trabecular bone (10 MPa).
ISSN:0954-4119
2041-3033
DOI:10.1243/0954411981534196