Effectiveness of immunoglobulin treatment in rats with experimental allergic encephalomyelitis

The aim of our study was to investigate effectiveness ofintravenous immunoglobulin treatment at experimental allergic encephalomyelitis (EAE). EAE was induced by the administration of adult rat spinal cord homogenates with Freund's adjuvant. All rats were divided into three groups: the first gr...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2005, Vol.51 (6), p.37-39
Main Authors: Mel'nyk, V O, Lisianyĭ, M I, Biel's'ka, L M, Shniakin, S A
Format: Article
Language:Ukrainian
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - therapeutic use
Animals
Encephalomyelitis, Autoimmune, Experimental - drug therapy
Encephalomyelitis, Autoimmune, Experimental - immunology
Humans
Immunoglobulins, Intravenous - administration & dosage
Immunoglobulins, Intravenous - therapeutic use
Injections, Intraperitoneal
Rats
Treatment Outcome
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Summary:The aim of our study was to investigate effectiveness ofintravenous immunoglobulin treatment at experimental allergic encephalomyelitis (EAE). EAE was induced by the administration of adult rat spinal cord homogenates with Freund's adjuvant. All rats were divided into three groups: the first group received intraperitoneal injections of human intravenous immunoglobulin in dose 0.5 g/kg from 12th to 16th day after induction of EAE; the second group received intraperitoneal injections of rat intravenous immunoglobulin in dose 0.5 g/kg from 12th to 15th day after induction of EAE; and the third group was a control group. We observed more rapid and full recovery from EAE in rats treated with intravenous immunoglobulin.
ISSN:2522-9028