A Case of Extensive Linear Porokeratosis with Evaluation of Topical Tretinoin versus 5‐Flourouracil as Treatment Modalities

A 19‐year‐old male presented with linear raised lesions over extensive areas of his body that followed Blaschko's lines. The lesions were asymptomatic with ridged borders. Histopathology confirmed a diagnosis of porokeratosis. He was given topical tretinoin and topical flourouracil for local ap...

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Bibliographic Details
Published in:Journal of dermatology 2005-12, Vol.32 (12), p.1000-1004
Main Authors: Grover, Chander, Goel, Alka, Nanda, Soni, Khurana, Nita, Reddy, Belum Siva Nagi
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Biopsy, Needle
Dose-Response Relationship, Drug
Drug Administration Schedule
Evaluation Studies as Topic
flourouracil
Fluorouracil - therapeutic use
Follow-Up Studies
Humans
Immunohistochemistry
linear porokeratosis
Male
Porokeratosis - diagnosis
Porokeratosis - drug therapy
Porokeratosis - pathology
Risk Assessment
Severity of Illness Index
Treatment Outcome
tretinoin
Tretinoin - therapeutic use
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Description
Summary:A 19‐year‐old male presented with linear raised lesions over extensive areas of his body that followed Blaschko's lines. The lesions were asymptomatic with ridged borders. Histopathology confirmed a diagnosis of porokeratosis. He was given topical tretinoin and topical flourouracil for local application on specified areas. The cosmetic acceptability and the safety profile of tretinoin were found to be better than those of flourouracil. However, both the agents were equally efficacious. A rare case of extensive porokeratosis with comparative evaluation of two treatment modalities is hereby presented.
ISSN:0385-2407
1346-8138
DOI:10.1111/j.1346-8138.2005.tb00890.x