Dynamics of leukocytes' migration degree in oral cavity and parameters of INFgamma and TNFalpha in blood serum of patients suffering from parodontitis on the background of treatment with Unimag

In the oral cavity of patients with parodontitis before treatment the quantity of migrated leukocytes (ML) was increased. Among them number of living cells was sharply reduced. In the process of treatment on the background of immune modulation with Unimag, the concentration of migrated leukocytes de...

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Bibliographic Details
Published in:Georgian medical news 2005-12 (129), p.44-47
Main Authors: Saralidze, M G, Dzhashi, L M, Tskitishvili, T G, Gogebashvili, N N, Surguladze, B V
Format: Article
Language:Russian
Subjects:
Chemotaxis, Leukocyte - drug effects
Enzyme-Linked Immunosorbent Assay
Ferrosoferric Oxide - pharmacology
Ferrosoferric Oxide - therapeutic use
Humans
Immunologic Factors - pharmacology
Immunologic Factors - therapeutic use
Interferon-gamma - blood
Mouth - drug effects
Periodontal Diseases - blood
Periodontal Diseases - therapy
Time Factors
Tumor Necrosis Factor-alpha - metabolism
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Summary:In the oral cavity of patients with parodontitis before treatment the quantity of migrated leukocytes (ML) was increased. Among them number of living cells was sharply reduced. In the process of treatment on the background of immune modulation with Unimag, the concentration of migrated leukocytes decreases and number of living leukocytes increases. The above-mentioned quantitative and qualitative parameters of migrated leukocytes were normalized after 1-1.5 months. The analogical dynamics has been detected in patients suffering from parodontitis and treated with traditional scheme. However, despite reduced concentration of migrated leukocytes and increased percentage of living leukocytes' content, normalization of the mentioned parameters has not been detected. In the blood serum of patients suffering from parodontitis increased concentration of INFgamma and TNFalpha have been revealed. In the process of treatment, concentration of the mentioned cytokines was decreased, however, in patients treated with Unimag on the background of immune modulation, decrease in concentration of INFgamma and TNFalpha was much more expressed.
ISSN:1512-0112