Effects of bradykinin and capsaicin intramuscular injections on stretch-evoked postsynaptic response of motoneurones of the gastrocnemius-soleus muscle

Responses of gastrocnemius-soleus motoneurones to stretches of the homonymous muscles were recorded intracellularly in the decerebrated cats during intramuscular injections (IMI) of bradykinin or capsaicin into the muscles. Effects of IMI on EPSPs and spikes evoked by stretches of the G-S muscles we...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2005, Vol.51 (6), p.30-36
Main Authors: Buhaĭchenko, L A, Piliavs'kyĭ, O I, Kostiukov, O I
Format: Article
Language:Ukrainian
Subjects:
Animals
Bradykinin - administration & dosage
Bradykinin - pharmacology
Capsaicin - administration & dosage
Capsaicin - pharmacology
Cats
Excitatory Postsynaptic Potentials - drug effects
Injections, Intramuscular
Male
Motor Neurons - drug effects
Motor Neurons - physiology
Muscle Spindles - drug effects
Muscle Spindles - physiology
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiology
Pain - physiopathology
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Summary:Responses of gastrocnemius-soleus motoneurones to stretches of the homonymous muscles were recorded intracellularly in the decerebrated cats during intramuscular injections (IMI) of bradykinin or capsaicin into the muscles. Effects of IMI on EPSPs and spikes evoked by stretches of the G-S muscles were studied in 6 motoneurones. Stretch-evoked EPSPs and firing were predominantly suppressed after IMIs, with the exception of slight increase of EPSPs up to 150 s after bradykinin injection, followed by theirs distinct decrease. The suppression of spike activity was followed by restoration within 500-800 s after bradykinin injection. Stretch-evoked EPSPs and firing were depressed after capsaicin injection; control level of motoneurones activity was seemed to be unrecoverable for quite a long time. No background IPSPs were observed after algesic injections and presynaptic inhibition was considered as plausible reason for the observed suppression of motoneurones activity.
ISSN:2522-9028