[ [formula omitted]]Rilmenidine-labelled imidazoline-receptor binding sites co-localize with [ [formula omitted]]2-(benzofuranyl)-2-imidazoline-labelled imidazoline-receptor binding sites and monoamine oxidase-B in rabbit, but not rat, kidney

• Published in: Journal of the autonomic nervous system 1998-10, Vol.72 (2), p.118-128
• Main Authors: King, Paul R., Suzuki, Satoshi, Hosseini, Ali R., Iakovidis, Dimitri, Nero, Tracy L., Jackman, Graham P., J. Louis, William, Gundlach, Andrew L.
• Format: Article
• Language: English
• Subjects: [ [formula omitted]]19-6327; [ [formula omitted]]2-BFI; [ [formula omitted]]Rilmenidine; [ [formula omitted]]RO41-1049; Adrenergic alpha-Agonists - metabolism; Animals; Autoradiography; Benzofurans - metabolism; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Imidazoles - metabolism; Imidazoline Receptors; Imidazoline-receptor binding site; In Vitro Techniques; Isoenzymes - metabolism; Kidney; Kidney - enzymology; Kidney - metabolism; Male; Monoamine oxidase; Monoamine Oxidase - metabolism; Monoamine Oxidase Inhibitors - metabolism; Oxazoles - metabolism; Picolinic Acids - metabolism; Rabbit; Rabbits; Rat; Rats; Rats, Inbred WKY; Receptors, Drug - metabolism; Rilmenidine; Species Specificity; Thiazoles - metabolism; Vertebrates: urinary system
• ISSN: 0165-1838; 1872-7476
• DOI: 10.1016/S0165-1838(98)00096-4

The distribution and relative densities of imidazoline-receptor binding sites (I-RBS) and monoamine oxidase (MAO)-A and -B enzyme(s) in rat and rabbit kidney were compared autoradiographically using fixed nanomolar concentrations of [ 3 H ]rilmenidine and [ 3 H ]2-(benzofuranyl)-2-imidazoline ([ 3 H ]2-BFI) to label I-RBS, and [ 3 H ]RO41-1049 and [ 3 H ]RO19-6327 to label MAO-A and -B isoenzymes, respectively. In rat kidney, high densities of I-RBS labelled by [ 3 H ]rilmenidine were observed in the cortex and outer stripe (120–280 fmol/mg tissue), in contrast to low I-RBS densities labelled by [ 3 H ]2-BFI (