Analysis of Ehrlichial p28 Gene Expression in a Murine Model of Persistent Infection

: Historically, ehrlichioses were tick‐borne diseases of veterinary medical importance and are now important emerging infectious diseases in humans. p28s are encoded by multigene families with ORFs tandemly arranged with intergenic spaces of variable lengths. We reported initial sequencing of the Eh...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-12, Vol.1063 (1), p.420-424
Main Authors: CROCQUET-VALDES, PATRICIA A., McBRIDE, JERE W., FENG, HUI-MIN, ISMAIL, NAHED, SMALL, MELISSA A., YU, XUE-JIE, WALKER, DAVID H.
Format: Article
Language:English
Subjects:
Animals
Bacterial Outer Membrane Proteins - biosynthesis
Bacterial Outer Membrane Proteins - genetics
Chronic Disease
Disease Models, Animal
Ehrlichia
Ehrlichia - genetics
Ehrlichia muris
Ehrlichiosis - microbiology
Gene Expression Regulation, Bacterial
Mice
Molecular Sequence Data
multigene family
outer membrane proteins
RT-PCR
Sequence Analysis, DNA
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Summary:: Historically, ehrlichioses were tick‐borne diseases of veterinary medical importance and are now important emerging infectious diseases in humans. p28s are encoded by multigene families with ORFs tandemly arranged with intergenic spaces of variable lengths. We reported initial sequencing of the Ehrlichia muris p28 locus. A model of persistent infection was described and provided tools for study of persistent ehrlichial infection. We completed the sequence of the E. muris p28 locus and examined mRNA expression.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1355.076