The susceptibility of anaerobic bacteria isolated from periodontal diseases to photodynamic inactivation with Fotolon (chlorin e6)

Photodynamic inactivation (PDI) may be a very promising alternative method for the antimicrobial treatment of periodontitis. Several studies have demonstrated the sensitivity of subgingival flora to PDI using toluidine blue, methylene blue, and chlorin e6 derivatives. In the present study we report...

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Bibliographic Details
Published in:Polish journal of microbiology 2005, Vol.54 (4), p.305-310
Main Authors: Drulis-Kawa, Zuzanna, Bednarkiewicz, Artur, Bugla-Płoskonska, Gabriela, Strek, Wiesław, Doroszkiewicz, Włodzimierz
Format: Article
Language:English
Subjects:
Anaerobic bacteria
Bacteria, Anaerobic - drug effects
Bacteria, Anaerobic - isolation & purification
Gram-Negative Anaerobic Bacteria - drug effects
Gram-Negative Anaerobic Bacteria - isolation & purification
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - isolation & purification
Humans
In Vitro Techniques
Inactivation
Periodontal diseases
Periodontal Diseases - drug therapy
Periodontal Diseases - microbiology
Photochemotherapy
Photosensitizing Agents - pharmacology
Porphyrins - pharmacology
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Summary:Photodynamic inactivation (PDI) may be a very promising alternative method for the antimicrobial treatment of periodontitis. Several studies have demonstrated the sensitivity of subgingival flora to PDI using toluidine blue, methylene blue, and chlorin e6 derivatives. In the present study we report the activity of the Fotolon sensitizer, composed of chlorin e6 and polyvinylpyrrolidone (PVP), against anaerobic bacteria isolated from periodontal diseases. Over 99.9% reduction in colony forming units in 20 Gram-positive and 30 Gram-negative clinical anaerobic strains was obtained.
ISSN:1733-1331
2544-4646