Abnormalities in the upper gastrointestinal tract in inflammatory bowel disease

The predominant histopathologic feature of inflammatory bowel disease is the infiltration of acute and chronic inflammatory cells, including polymorphonuclear neutrophils, macrophages and lymphocytes, in the affected intestine. Helicobacter pylori is recognized as the most common cause of upper gast...

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Bibliographic Details
Published in:Inflammopharmacology 2007-06, Vol.15 (3), p.101-104
Main Authors: Ando, T, Nobata, K, Watanabe, O, Kusugami, K, Maeda, O, Ishiguro, K, Ohmiya, N, Niwa, Y, Goto, H
Format: Article
Language:English
Subjects:
Chemokines - physiology
Crohn Disease - immunology
Crohn Disease - microbiology
Crohn Disease - pathology
Cytokines - physiology
Endoscopy, Gastrointestinal
Helicobacter Infections - epidemiology
Helicobacter pylori
Humans
Upper Gastrointestinal Tract - pathology
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Summary:The predominant histopathologic feature of inflammatory bowel disease is the infiltration of acute and chronic inflammatory cells, including polymorphonuclear neutrophils, macrophages and lymphocytes, in the affected intestine. Helicobacter pylori is recognized as the most common cause of upper gastrointestinal lesions, and Helicobacter pylori-associated gastritis is characterized by increased numbers of acute and chronic inflammatory cells. The pathogenesis of inflammatory bowel disease or Helicobacter pylori-associated gastritis involves immunological abnormalities, including the deficient or excessive expression of cytokines. The chronic inflammatory process in patients with Crohn's disease may affect any part of the gastrointestinal tract, whereas ulcerative colitis affects mainly the colon and rectum. Here, we discuss abnormalities in the upper gastrointestinal tract in inflammatory bowel disease. Although the prevalence rate of Helicobacter pylori infection is low in Crohn's disease, these patients often have abnormalities in the upper gastrointestinal tract.
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-006-0735-1