Isolation of stigmasterol and beta-sitosterol from methanolic extract of root bark of Calotropis gigantea (Linn)

Aim of this study is to identify and characterize the bioactive principles from the root bark of Calotropis gigantea. It has wide folk medicinal use. For isolation of the compounds, the dried root bark's powder of Calotropis gigantea were subjected to hot extraction and then the crude methanol...

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Bibliographic Details
Published in:Pakistan journal of biological sciences 2007-11, Vol.10 (22), p.4174-4176
Main Authors: Habib, M Rowshanul, Nikkon, Farjana, Rahman, Matiar, Haque, M Ekramul, Karim, M Rezaul
Format: Article
Language:English
Subjects:
Acetates - analysis
Alcohols - chemistry
Alkanes - analysis
Calotropis - metabolism
Chloroform - analysis
Hot Temperature
Magnetic Resonance Spectroscopy
Mass Spectrometry - methods
Methanol - chemistry
Methanol - pharmacology
Models, Chemical
Plant Roots - metabolism
Sitosterols - analysis
Sitosterols - chemistry
Sitosterols - isolation & purification
Spectrophotometry - methods
Stigmasterol - analysis
Stigmasterol - isolation & purification
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Summary:Aim of this study is to identify and characterize the bioactive principles from the root bark of Calotropis gigantea. It has wide folk medicinal use. For isolation of the compounds, the dried root bark's powder of Calotropis gigantea were subjected to hot extraction and then the crude methanol (MeOH) extract was fractionated with petroleum ether, chloroform and ethyl acetate. Two compounds were isolated and purified from petroleum ether fraction of crude methanol extract and the structures were determined as stigmasterol and beta-sitosterol by analysis of physical, chemical and spectral characteristics (1D NMR and mass spectrometry).
ISSN:1028-8880
DOI:10.3923/pjbs.2007.4174.4176