NS5ATP9, a gene up-regulated by HCV NS5A protein

Abstract Non-structural protein 5A (NS5A) appears to interact with a variety of cellular proteins and play an important role in mediating cell growth, cellular signaling pathways and pathogenesis of hepatitis C virus (HCV). NS5ATP9 was identified as a NS5A trans-activated protein in suppression subt...

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Bibliographic Details
Published in:Cancer letters 2008-02, Vol.259 (2), p.192-197
Main Authors: Shi, Lei, Zhang, Shu-lin, Li, Kang, Hong, Yuan, Wang, Qi, Li, Yue, Guo, Jiang, Fan, Wan-hu, Zhang, Lei, Cheng, Jun
Format: Article
Language:English
Subjects:
Base Sequence
Bioinformatics
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - virology
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell culture
Cell growth
Cell Line, Tumor
Cloning
Cloning, Molecular
Deoxyribonucleic acid
DNA
DNA-Binding Proteins
Efficiency
Gene expression
Gene Expression Regulation, Neoplastic
Gene Library
Genes, Reporter
Genomes
HCV NS5A protein
Hematology, Oncology and Palliative Medicine
Hepacivirus - genetics
Hepacivirus - metabolism
Hepacivirus - pathogenicity
Hepatitis C - complications
Hepatitis C - genetics
Hepatitis C - metabolism
Hepatitis C virus
Humans
Liver cancer
Liver Neoplasms - genetics
Liver Neoplasms - metabolism
Liver Neoplasms - virology
Molecular Sequence Data
NS5ATP9
Pathogenesis
Polymerase Chain Reaction
Promoter
Promoter Regions, Genetic
Proteins
qRT-PCR
RNA, Messenger - metabolism
SSH
Transcriptional Activation
Transfection
Up-Regulation
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - metabolism
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Summary:Abstract Non-structural protein 5A (NS5A) appears to interact with a variety of cellular proteins and play an important role in mediating cell growth, cellular signaling pathways and pathogenesis of hepatitis C virus (HCV). NS5ATP9 was identified as a NS5A trans-activated protein in suppression subtractive hybridization (SSH), and the regulation was confirmed by luciferase reporter assay and quantitative real time PCR (qRT-PCR). A minimal promoter region contained within the 211 bp (nucleotides −161 to +50 bp) immediately upstream of the transcription initiation site. NS5ATP9 is a NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2007.10.029