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NS5ATP9, a gene up-regulated by HCV NS5A protein
Abstract Non-structural protein 5A (NS5A) appears to interact with a variety of cellular proteins and play an important role in mediating cell growth, cellular signaling pathways and pathogenesis of hepatitis C virus (HCV). NS5ATP9 was identified as a NS5A trans-activated protein in suppression subt...
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| Published in: | Cancer letters 2008-02, Vol.259 (2), p.192-197 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c389t-b556b4fade0365e89b4dbc0d5b6e3e5661659f327db9be5169f25c22f82d676d3 |
| container_end_page | 197 |
| container_issue | 2 |
| container_start_page | 192 |
| container_title | Cancer letters |
| container_volume | 259 |
| creator | Shi, Lei Zhang, Shu-lin Li, Kang Hong, Yuan Wang, Qi Li, Yue Guo, Jiang Fan, Wan-hu Zhang, Lei Cheng, Jun |
| description | Abstract Non-structural protein 5A (NS5A) appears to interact with a variety of cellular proteins and play an important role in mediating cell growth, cellular signaling pathways and pathogenesis of hepatitis C virus (HCV). NS5ATP9 was identified as a NS5A trans-activated protein in suppression subtractive hybridization (SSH), and the regulation was confirmed by luciferase reporter assay and quantitative real time PCR (qRT-PCR). A minimal promoter region contained within the 211 bp (nucleotides −161 to +50 bp) immediately upstream of the transcription initiation site. NS5ATP9 is a NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma. |
| doi_str_mv | 10.1016/j.canlet.2007.10.029 |
| format | article |
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NS5ATP9 was identified as a NS5A trans-activated protein in suppression subtractive hybridization (SSH), and the regulation was confirmed by luciferase reporter assay and quantitative real time PCR (qRT-PCR). A minimal promoter region contained within the 211 bp (nucleotides −161 to +50 bp) immediately upstream of the transcription initiation site. NS5ATP9 is a NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2007.10.029</identifier><identifier>PMID: 18068894</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Base Sequence ; Bioinformatics ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - virology ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cell culture ; Cell growth ; Cell Line, Tumor ; Cloning ; Cloning, Molecular ; Deoxyribonucleic acid ; DNA ; DNA-Binding Proteins ; Efficiency ; Gene expression ; Gene Expression Regulation, Neoplastic ; Gene Library ; Genes, Reporter ; Genomes ; HCV NS5A protein ; Hematology, Oncology and Palliative Medicine ; Hepacivirus - genetics ; Hepacivirus - metabolism ; Hepacivirus - pathogenicity ; Hepatitis C - complications ; Hepatitis C - genetics ; Hepatitis C - metabolism ; Hepatitis C virus ; Humans ; Liver cancer ; Liver Neoplasms - genetics ; Liver Neoplasms - metabolism ; Liver Neoplasms - virology ; Molecular Sequence Data ; NS5ATP9 ; Pathogenesis ; Polymerase Chain Reaction ; Promoter ; Promoter Regions, Genetic ; Proteins ; qRT-PCR ; RNA, Messenger - metabolism ; SSH ; Transcriptional Activation ; Transfection ; Up-Regulation ; Viral Nonstructural Proteins - genetics ; Viral Nonstructural Proteins - metabolism</subject><ispartof>Cancer letters, 2008-02, Vol.259 (2), p.192-197</ispartof><rights>2007</rights><rights>Copyright Elsevier Limited Feb 8, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-b556b4fade0365e89b4dbc0d5b6e3e5661659f327db9be5169f25c22f82d676d3</citedby><cites>FETCH-LOGICAL-c389t-b556b4fade0365e89b4dbc0d5b6e3e5661659f327db9be5169f25c22f82d676d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18068894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Lei</creatorcontrib><creatorcontrib>Zhang, Shu-lin</creatorcontrib><creatorcontrib>Li, Kang</creatorcontrib><creatorcontrib>Hong, Yuan</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Li, Yue</creatorcontrib><creatorcontrib>Guo, Jiang</creatorcontrib><creatorcontrib>Fan, Wan-hu</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Cheng, Jun</creatorcontrib><title>NS5ATP9, a gene up-regulated by HCV NS5A protein</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Abstract Non-structural protein 5A (NS5A) appears to interact with a variety of cellular proteins and play an important role in mediating cell growth, cellular signaling pathways and pathogenesis of hepatitis C virus (HCV). NS5ATP9 was identified as a NS5A trans-activated protein in suppression subtractive hybridization (SSH), and the regulation was confirmed by luciferase reporter assay and quantitative real time PCR (qRT-PCR). A minimal promoter region contained within the 211 bp (nucleotides −161 to +50 bp) immediately upstream of the transcription initiation site. NS5ATP9 is a NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma.</description><subject>Base Sequence</subject><subject>Bioinformatics</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell culture</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cloning</subject><subject>Cloning, Molecular</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA-Binding Proteins</subject><subject>Efficiency</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Library</subject><subject>Genes, Reporter</subject><subject>Genomes</subject><subject>HCV NS5A protein</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hepacivirus - genetics</subject><subject>Hepacivirus - metabolism</subject><subject>Hepacivirus - pathogenicity</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - genetics</subject><subject>Hepatitis C - metabolism</subject><subject>Hepatitis C virus</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - virology</subject><subject>Molecular Sequence Data</subject><subject>NS5ATP9</subject><subject>Pathogenesis</subject><subject>Polymerase Chain Reaction</subject><subject>Promoter</subject><subject>Promoter Regions, Genetic</subject><subject>Proteins</subject><subject>qRT-PCR</subject><subject>RNA, Messenger - metabolism</subject><subject>SSH</subject><subject>Transcriptional Activation</subject><subject>Transfection</subject><subject>Up-Regulation</subject><subject>Viral Nonstructural Proteins - genetics</subject><subject>Viral Nonstructural Proteins - metabolism</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkU1rFEEQhhtRzCb6D0QGhJwya_V390UIixohqJDotZnurgmzzs6s3TPC_nt72IVALjkVFE-9RT1FyDsKawpUfdyuQzP0OK0ZgC6tNTD7gqyo0azW1sBLsgIOouaGyzNynvMWAKTQ8jU5owaUMVasCHy_k9f3P-1V1VQPOGA17-uED3PfTBgrf6huNr-rhan2aZywG96QV23TZ3x7qhfk15fP95ub-vbH12-b69s6cGOn2kupvGibiMCVRGO9iD5AlF4hR6kUVdK2nOnorUdJlW2ZDIy1hkWlVeQX5PKYW_b-nTFPbtflgH3fDDjO2WmgkgrFnwWLngVUBfzwBNyOcxrKEY7KxYzgVhZKHKmQxpwTtm6ful2TDo6CW8S7rTuKX5L10i3iy9j7U_jsdxgfh06mC_DpCGCR9q_D5HLocAgYu4RhcnHsntvwNCD03dCFpv-DB8yPt7jMHLi75fnL70EDCG0M_w-Ub6ZK</recordid><startdate>20080208</startdate><enddate>20080208</enddate><creator>Shi, Lei</creator><creator>Zhang, Shu-lin</creator><creator>Li, Kang</creator><creator>Hong, Yuan</creator><creator>Wang, Qi</creator><creator>Li, Yue</creator><creator>Guo, Jiang</creator><creator>Fan, Wan-hu</creator><creator>Zhang, Lei</creator><creator>Cheng, Jun</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080208</creationdate><title>NS5ATP9, a gene up-regulated by HCV NS5A protein</title><author>Shi, Lei ; Zhang, Shu-lin ; Li, Kang ; Hong, Yuan ; Wang, Qi ; Li, Yue ; Guo, Jiang ; Fan, Wan-hu ; Zhang, Lei ; Cheng, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-b556b4fade0365e89b4dbc0d5b6e3e5661659f327db9be5169f25c22f82d676d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Base Sequence</topic><topic>Bioinformatics</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell culture</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cloning</topic><topic>Cloning, Molecular</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA-Binding Proteins</topic><topic>Efficiency</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Library</topic><topic>Genes, Reporter</topic><topic>Genomes</topic><topic>HCV NS5A protein</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hepacivirus - genetics</topic><topic>Hepacivirus - metabolism</topic><topic>Hepacivirus - pathogenicity</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - genetics</topic><topic>Hepatitis C - metabolism</topic><topic>Hepatitis C virus</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - virology</topic><topic>Molecular Sequence Data</topic><topic>NS5ATP9</topic><topic>Pathogenesis</topic><topic>Polymerase Chain Reaction</topic><topic>Promoter</topic><topic>Promoter Regions, Genetic</topic><topic>Proteins</topic><topic>qRT-PCR</topic><topic>RNA, Messenger - metabolism</topic><topic>SSH</topic><topic>Transcriptional Activation</topic><topic>Transfection</topic><topic>Up-Regulation</topic><topic>Viral Nonstructural Proteins - genetics</topic><topic>Viral Nonstructural Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Lei</creatorcontrib><creatorcontrib>Zhang, Shu-lin</creatorcontrib><creatorcontrib>Li, Kang</creatorcontrib><creatorcontrib>Hong, Yuan</creatorcontrib><creatorcontrib>Wang, Qi</creatorcontrib><creatorcontrib>Li, Yue</creatorcontrib><creatorcontrib>Guo, Jiang</creatorcontrib><creatorcontrib>Fan, Wan-hu</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Cheng, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Lei</au><au>Zhang, Shu-lin</au><au>Li, Kang</au><au>Hong, Yuan</au><au>Wang, Qi</au><au>Li, Yue</au><au>Guo, Jiang</au><au>Fan, Wan-hu</au><au>Zhang, Lei</au><au>Cheng, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NS5ATP9, a gene up-regulated by HCV NS5A protein</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2008-02-08</date><risdate>2008</risdate><volume>259</volume><issue>2</issue><spage>192</spage><epage>197</epage><pages>192-197</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Abstract Non-structural protein 5A (NS5A) appears to interact with a variety of cellular proteins and play an important role in mediating cell growth, cellular signaling pathways and pathogenesis of hepatitis C virus (HCV). NS5ATP9 was identified as a NS5A trans-activated protein in suppression subtractive hybridization (SSH), and the regulation was confirmed by luciferase reporter assay and quantitative real time PCR (qRT-PCR). A minimal promoter region contained within the 211 bp (nucleotides −161 to +50 bp) immediately upstream of the transcription initiation site. NS5ATP9 is a NS5A up-regulation gene which may play a role in the pathogenesis of HCV-associated hepatocellular carcinoma.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>18068894</pmid><doi>10.1016/j.canlet.2007.10.029</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2008-02, Vol.259 (2), p.192-197 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | Elsevier |
| subjects | Base Sequence Bioinformatics Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - virology Carrier Proteins - genetics Carrier Proteins - metabolism Cell culture Cell growth Cell Line, Tumor Cloning Cloning, Molecular Deoxyribonucleic acid DNA DNA-Binding Proteins Efficiency Gene expression Gene Expression Regulation, Neoplastic Gene Library Genes, Reporter Genomes HCV NS5A protein Hematology, Oncology and Palliative Medicine Hepacivirus - genetics Hepacivirus - metabolism Hepacivirus - pathogenicity Hepatitis C - complications Hepatitis C - genetics Hepatitis C - metabolism Hepatitis C virus Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - virology Molecular Sequence Data NS5ATP9 Pathogenesis Polymerase Chain Reaction Promoter Promoter Regions, Genetic Proteins qRT-PCR RNA, Messenger - metabolism SSH Transcriptional Activation Transfection Up-Regulation Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism |
| title | NS5ATP9, a gene up-regulated by HCV NS5A protein |
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