Molecular Imaging of Reporter Gene Expression in Prostate Cancer: An Overview

Prostate cancer remains an important and growing health problem. Advances in imaging of prostate cancer may help to achieve earlier and more accurate diagnosis and treatment. We review the various strategies using reporter genes for molecular imaging of prostate cancer. These approaches are emerging...

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Bibliographic Details
Published in:Seminars in nuclear medicine 2008, Vol.38 (1), p.9-19
Main Authors: Singh, Abhinav, MB, BS, BSc, MRCS, Massoud, Tarik F., MD, PhD, Deroose, Christophe, MD, PhD, Gambhir, Sanjiv S., MD, PhD
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Diagnostic Imaging - methods
Genes, Reporter
Humans
Male
Molecular Probe Techniques
Neoplasm Proteins - metabolism
Prostatic Neoplasms - diagnosis
Prostatic Neoplasms - metabolism
Radiology
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Summary:Prostate cancer remains an important and growing health problem. Advances in imaging of prostate cancer may help to achieve earlier and more accurate diagnosis and treatment. We review the various strategies using reporter genes for molecular imaging of prostate cancer. These approaches are emerging as valuable tools for monitoring gene expression in laboratory animals and humans. Further development of more sensitive and selective reporters, combined with improvements in detection technology, will consolidate the position of reporter gene imaging as a versatile method for understanding of intracellular biological processes and the underlying molecular basis of prostate cancer, as well as potentially establishing a future role in the clinical management of patients afflicted with this disease.
ISSN:0001-2998
1558-4623
DOI:10.1053/j.semnuclmed.2007.09.002