Highly active antiretroviral therapy and incidence of cervical squamous intraepithelial lesions among HIV-infected women with normal cytology and CD4 counts above 350 cells/mm3

• Published in: Journal of antimicrobial chemotherapy 2008-01, Vol.61 (1), p.191-194
• Main Authors: Sirera, Guillem, Videla, Sebastià, López-Blázquez, Raquel, Llatjos, Mariona, Tarrats, Antoni, Castellà, Eva, Grane, Nuria, Tural, Cristina, Rey-Joly, Celestino, Clotet, Bonaventura
• Format: Article
• Language: English
• Subjects: Adult; Anti-HIV Agents - administration & dosage; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiretroviral Therapy, Highly Active; Biological and medical sciences; CD4 Lymphocyte Count; Cervical Intraepithelial Neoplasia - epidemiology; Cervical Intraepithelial Neoplasia - pathology; Cervical Intraepithelial Neoplasia - virology; cervical SIL in HIV; Cervix Uteri - pathology; Cohort Studies; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; HAART; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - epidemiology; HIV Infections - immunology; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; immunological status; Immunopathology; Incidence; Infectious diseases; Medical sciences; Papanicolaou Test; Pharmacology. Drug treatments; Retrospective Studies; Tumors; Uterine Cervical Neoplasms - epidemiology; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - virology; Vaginal Smears; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; women
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkm412

Objectives To provide evidence for the long-term effect of highly active antiretroviral therapy (HAART) on the incidence of cervical squamous intraepithelial lesions (SILs) among HIV-positive women with normal cytology test and CD4 count above 350 cells/mm3. Patients and methods A retrospective cohort study was carried out in HIV-positive women with two consecutive normal cervical cytological tests (Papanicolaou test) and at least one subsequent test, without previous cervical history of SIL or cancer diagnosis, and with an immunological status >350 CD4 cells/mm3. The patients were divided into two groups: treated with HAART (HAART group) or not treated with HAART (NO-HAART group), during the period of time between cytology tests included in the survival analysis and time until SIL. Results Between January 1997 and December 2006, 127 women were included: 90 in the HAART group and 37 in the NO-HAART group. Both groups of patients were similar with respect to demographic data, except for HIV viral load and previous HAART inclusion (P < 0.001). SIL was diagnosed in 27 of 90 (30%) patients in the HAART group and in 7 of 37 (19%) patients in the NO-HAART group (OR = 1.84, 95% CI: 0.72–4.69, P = 0.202). The actuarial probability of remaining free of SIL at 3 years was 70% in the HAART group and 78% in the NO-HAART group. No variable was associated with an increased risk of developing SILs. Conclusions These results suggest that when the patients' immunological status is above 350 CD4 cells/mm3, the HIV-infected women treated with HAART present a similar cervical SIL incidence to women not on HAART.