Tryptamine derived amides with thiazole ring system from Thermoactinomyces strain TA66-2

A moderately thermophilic actinomycete strain, which was identified as Thermoactinomyces strain TA66‐2, was isolated from hot‐spring water. Fermentation, followed by solvent partition and chromatographic separations, resulted in the isolation of two new and two known molecules. The structures of the...

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Bibliographic Details
Published in:Magnetic resonance in chemistry 2008-01, Vol.46 (1), p.80-83
Main Authors: Korkmaz, Çaǧla Akmemiş, Hameş-Kocabaş, E. Esin, Uzel, Ataç, Bedir, Erdal
Format: Article
Language:English
Subjects:
13C NMR
1H NMR
2D NMR
actinomycete
Actinomycetes
Amides
Amides - isolation & purification
DNA, Bacterial - analysis
Fermentation
Magnetic Resonance Spectroscopy
Micromonosporaceae - chemistry
Micromonosporaceae - genetics
Micromonosporaceae - growth & development
Molecular Structure
Polymerase Chain Reaction
Solvents
Spectral methods
Spectrometry, Mass, Electrospray Ionization
Strain
Thermoactinomyces strain TA66-2
thiazole ring
Thiazoles - isolation & purification
tryptamine derivatives
Tryptamines - chemistry
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Summary:A moderately thermophilic actinomycete strain, which was identified as Thermoactinomyces strain TA66‐2, was isolated from hot‐spring water. Fermentation, followed by solvent partition and chromatographic separations, resulted in the isolation of two new and two known molecules. The structures of the new compounds were elucidated as 2‐(1‐Propionylaminoethyl)thiazole‐4‐carboxylic acid [2‐(1H‐indol‐3‐yl)ethyl]amide and 2‐(1‐Acetylaminoethyl)thiazole‐4‐carboxylic acid [2‐(1H‐indol‐3‐yl)‐ethyl]amide by using spectral methods (1D‐, 2D‐NMR and LC–ESI–MS). Copyright © 2007 John Wiley & Sons, Ltd.
ISSN:0749-1581
1097-458X
DOI:10.1002/mrc.2101