Elongation of Photoreceptor Outer Segment in Central Serous Chorioretinopathy

Purpose To investigate photoreceptor segment morphologic changes at the detached retina in central serous chorioretinopathy (CSC). Design Observational case series. Methods We measured and compared the distance between the internal limiting membrane (ILM) and the external limiting membrane (ELM), be...

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Bibliographic Details
Published in:American journal of ophthalmology 2008, Vol.145 (1), p.162-168.e1
Main Authors: Matsumoto, Hidetaka, Kishi, Shoji, Otani, Tetsuya, Sato, Taku
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Basement Membrane
Biological and medical sciences
Choroid Diseases - diagnosis
Female
Fourier Analysis
Humans
Male
Medical imaging
Medical sciences
Middle Aged
Miscellaneous
Ophthalmology
Photoreceptors
Prospective Studies
Retina
Retinal Detachment - diagnosis
Retinal Diseases - diagnosis
Retinopathies
Rod Cell Outer Segment - pathology
Serum
Tomography, Optical Coherence
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Summary:Purpose To investigate photoreceptor segment morphologic changes at the detached retina in central serous chorioretinopathy (CSC). Design Observational case series. Methods We measured and compared the distance between the internal limiting membrane (ILM) and the external limiting membrane (ELM), between the ELM and the photoreceptor inner and outer segment junction (IS/OS) at the central fovea, and the length of the longest outer segment in 20 consecutive CSC eyes and 10 normal eyes on Fourier domain optical coherence tomography (FD-OCT) images. We evaluated the correlation between the length of the outer segment and age, best-corrected visual acuity (BCVA), and symptom duration in CSC eyes and the correlation between retinal thickness from the ILM to ELM and the other parameters. Results The median distance between the ILM and ELM was 75 μm in the CSC eyes and was significantly ( P = .0001) shorter than the median 135 μm in normal eyes. The median distance between the ELM and IS/OS was 35 μm in normal eyes and CSC eyes. The median longest outer segment length in CSC eyes was 90 μm and was significantly ( P = .01) longer than the 60 μm in normal eyes. The outer segment length was not or weakly correlated with age ( rs = 0.38), BCVA ( rs = 0.09), or symptom duration ( rs = 0.19). The distance between the ILM and ELM was weakly correlated with age ( rs = 0.34), BCVA ( rs = 0.34), or symptom duration ( rs = 0.28). Conclusions FD-OCT showed elongation of photoreceptor outer segments and decreased thickness of the outer nuclear layer in CSC.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2007.08.024