Analysis of pressure-driven air bubble elimination in a microfluidic device

We report an analysis of pressure-driven bubble elimination for a gas-permeable microfluidic device. In this study, we described bubble elimination in a microfluidic device employing a gas permeation model and calculated the removal efficiency of bubbles. The correction factor for the simplified mod...

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Bibliographic Details
Published in:Lab on a chip 2008-01, Vol.8 (1), p.176-178
Main Authors: Kang, Joo H, Kim, Yu Chang, Park, Je-Kyun
Format: Article
Language:English
Subjects:
Air - analysis
Dimethylpolysiloxanes - chemistry
Microfluidics - instrumentation
Pressure
Silicones - chemistry
Solutions
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Summary:We report an analysis of pressure-driven bubble elimination for a gas-permeable microfluidic device. In this study, we described bubble elimination in a microfluidic device employing a gas permeation model and calculated the removal efficiency of bubbles. The correction factor for the simplified model was estimated with respect to the applied pressure. Based on the established model, the required time to remove a trapped bubble with a certain area was shown to be within an error of 11.58% by comparison with experimental results. Exploiting the model equation, we were able to completely remove the air bubbles appearing during the process of filling a microfluidic device with an aqueous solution.
ISSN:1473-0197
1473-0189
DOI:10.1039/b712672g