Remnant lipoprotein metabolism is improved more when body weight is reduced by exercise than by dietary restriction

• Published in: Clinica chimica acta 2008-02, Vol.388 (1), p.28-32
• Main Authors: Yamada, Tetsuo, Kurasawa, Shin-ichi, Matsuzaki, Masami, Tanaka, Akira
• Format: Article
• Language: English
• Subjects: Adult; Apolipoprotein B48; atherosclerosis index; blood glucose; Blood Glucose - metabolism; Body Weight - physiology; Body weight reduction; Caloric Restriction; Chylomicron Remnants - metabolism; Dietary restriction; Exercise; Exercise - physiology; Humans; immunoreactive insulin; Insulin - immunology; Insulin - metabolism; Insulin resistance; IRI; Lipid Metabolism; lipoprotein lipase; Lipoproteins - blood; Lipoproteins - metabolism; LPL; Male; Remnant lipoprotein; remnant-like particle; remnant-like particle-cholesterol; RLP; RLP-C; sdLDL-C; small dense low density lipoprotein-cholesterol
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2007.09.022

Remnant lipoprotein levels during weight-loss programs have not been examined in detail. We investigated the effects of reducing body weight by exercise and by dietary restriction on lipid metabolism including remnant-like particle-cholesterol (RLP-C) and apolipoprotein B48 (apo B48). Six adult male volunteers participated in 2 experiments over 10 days. The first 5 days were an adjustment period (energy intake, 2656 ±150 kcal/day; mean ± SEM). During the second 5 days, the participants either exercised on a bicycle ergometer to consume 886 ± 50 kcal/day or reduced their energy intake to 1770 ± 100 kcal/day. Serum triglyceride (TG) and RLP-C levels were significantly lower, whereas the increase in high density lipoprotein-cholesterol (HDL-C) level was significantly larger after exercise than after dietary restriction. We measured changes (Δ) in serum levels and identified positive correlations between Δ insulin and Δ TG, Δ apo B48 ( p < 0.05) and Δ RLP-C ( p = 0.050) only during exercise. Reducing body weight by exercise has more beneficial effects on lipid metabolism than a dietary approach, and improved insulin resistance accompanies the decrease of serum remnant lipoprotein levels.