Risk Factors for In-Hospital Mortality During Infective Endocarditis in Patients With Congenital Heart Disease

Despite developments in preventative and medical therapy, infective endocarditis (IE) carries a high rate of mortality. Risk factors for mortality are unknown in pediatric and adult patients with congenital heart disease (CHD). We determined the risk factors for in-hospital mortality in pediatric an...

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Bibliographic Details
Published in:The American journal of cardiology 2008, Vol.101 (1), p.114-118
Main Authors: Yoshinaga, Masao, MD, PhD, Niwa, Koichiro, MD, PhD, Niwa, Atsuko, MD, PhD, Ishiwada, Naruhiko, MD, PhD, Takahashi, Hideto, PhD, Echigo, Shigeyuki, MD, Nakazawa, Makoto, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Child
Child, Preschool
Cohort Studies
Cross Infection - microbiology
Cross Infection - mortality
Endocardial and cardiac valvular diseases
Endocarditis, Bacterial - microbiology
Endocarditis, Bacterial - mortality
Endocarditis, Bacterial - surgery
Female
Health Surveys
Heart
Heart Defects, Congenital - epidemiology
Heart Failure - mortality
Heart surgery
Hospital Mortality
Humans
Infant
Infant, Newborn
Japan - epidemiology
Logistic Models
Male
Medical sciences
Middle Aged
Mortality
Regression analysis
Retrospective Studies
Risk Factors
Staphylococcal Infections - mortality
Staphylococcus aureus - isolation & purification
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Summary:Despite developments in preventative and medical therapy, infective endocarditis (IE) carries a high rate of mortality. Risk factors for mortality are unknown in pediatric and adult patients with congenital heart disease (CHD). We determined the risk factors for in-hospital mortality in pediatric and adult patients with CHD. A retrospective observational cohort study was conducted from January 1997 to December 2001 in Japan. Of the 239 patients for whom complete data were available, 216 patients with CHD were identified. Outcomes were alive or deceased. The proposed modified Duke’s criteria identified 137 patients, aged 1 month to 62 years with a median of 12 years, with IE. In-hospital mortality was 10%. Four risk factors were independently associated with mortality by stepwise logistic regression analysis: (1) vegetation size ≥20 mm (odds ratio 40.6, 95% confidence interval 2.42 to 681); (2) age
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2007.07.054