Oral undifferentiated high-grade pleomorphic sarcoma: report of a case

The current World Health Organization classification considers the existence of an undifferentiated unclassifiable category of pleomorphic sarcomas, defined as a group of pleomorphic high-grade sarcomas. Undifferentiated high-grade pleomorphic sarcoma represents about 5% of all soft tissue sarcomas...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 2008, Vol.105 (1), p.e37-e40
Main Authors: Alfredo, Edson, DDS, MSc, de Pádua, Joubert Magalhães, DDS, PhD, Vicentini, Eduardo Luis, DDS, Marchesan, Melissa Andreia, DDS, MSc, Comelli Lia, Raphael Carlos, DDS, PhD, da Cruz Perez, Danyel Elias, DDS, PhD, Silva-Sousa, Yara Teresinha Corrêa, DDS, PhD
Format: Article
Language:English
Subjects:
Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Dentistry
Diagnosis, Differential
Humans
Male
Middle Aged
Mouth Floor - pathology
Mouth Floor - surgery
Mouth Neoplasms - classification
Mouth Neoplasms - pathology
Mouth Neoplasms - therapy
Sarcoma - classification
Sarcoma - pathology
Sarcoma - therapy
Surgery
Vimentin - analysis
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Summary:The current World Health Organization classification considers the existence of an undifferentiated unclassifiable category of pleomorphic sarcomas, defined as a group of pleomorphic high-grade sarcomas. Undifferentiated high-grade pleomorphic sarcoma represents about 5% of all soft tissue sarcomas in adults and occurs more commonly in the extremities. In the oral cavity, undifferentiated pleomorphic sarcoma is extremely rare. We report a case of undifferentiated high-grade pleomorphic sarcoma located in the floor of the mouth in a man 56 years old. Microscopically, spindle-shaped cells with accented pleomorphism arranged in a storiform pattern, several bizarre giant cells, and frequent atypical mitoses were observed. The tumor cells were positive only for vimentin, with focal positivity for CD68. The patient was treated by surgery and postoperative radiation therapy, and after 25 months, no recurrence was observed.
ISSN:1079-2104
1528-395X
DOI:10.1016/j.tripleo.2007.07.023