Gene therapy with cytokines against cervical cancer

Gene therapy is an excellent alternative for treatment of many diseases. Capacity to manipulate the DNA has allowed direct the gene therapy to correct the function of an altered gene, to increase the expression of a gene and to favour the activation of the immune response. This way, it can intend th...

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Bibliographic Details
Published in:Salud pública de México 2005-11, Vol.47 (6), p.458-468
Main Authors: Bermúdez-Morales, Victor Hugo, Peralta-Zaragoza, Oscar, Madrid-Marina, Vicente
Format: Article
Language:Spanish
Subjects:
Cytokines - physiology
Female
Genetic Therapy - methods
Humans
Uterine Cervical Neoplasms - immunology
Uterine Cervical Neoplasms - therapy
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Summary:Gene therapy is an excellent alternative for treatment of many diseases. Capacity to manipulate the DNA has allowed direct the gene therapy to correct the function of an altered gene, to increase the expression of a gene and to favour the activation of the immune response. This way, it can intend the use of the DNA like medication able to control, to correct or to cure many diseases. Gene therapy against cancer has an enormous potential, and actually the use of the DNA has increased to control diverse cancer in animal models, with very encouraging results that have allowed its applications in experimental protocols in human. This work concentrates a review of the foundations of the gene therapy and its application on cervical cancer, from the point of view of the alterations of the immune system focused on the tumour micro-environment, and the use of the cytokines as immunomodulators.
ISSN:0036-3634
DOI:10.1590/S0036-36342005000600011