Effects of sildenafil on the fetal growth of guinea pigs and their ability to survive induced intrapartum asphyxia

Objective Our goal was to determine whether sildenafil increased fetal weight and favored fetal tolerance to induced asphyxia at birth in guinea pigs. Study Design Twenty guinea pigs were randomly allocated to placebo (n = 10) or sildenafil 50 μg/kg (n = 5) or 500 μg/kg (n = 5), starting from day 35...

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Published in:American journal of obstetrics and gynecology 2008, Vol.198 (1), p.127.e1-127.e6
Main Authors: Sánchez-Aparicio, Pedro, DVM, Mota-Rojas, Daniel, PhD, Nava-Ocampo, Alejandro A., MD, Trujillo-Ortega, Maria Elena, PhD, Alfaro-Rodríguez, Alfonso, PhD, Arch, Emilio, PhD, Alonso-Spilsbury, María, PhD
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Delivery. Postpartum. Lactation
Disease Models, Animal
Dose-Response Relationship, Drug
Female
fetal body weight
Fetal Development - drug effects
Fetal Hypoxia - drug therapy
fetal organ maturity
Fetal Organ Maturity - drug effects
Fetal Organ Maturity - physiology
fetal structures
Fetal Weight - drug effects
Guinea Pigs
Gynecology. Andrology. Obstetrics
Medical sciences
Obstetrics and Gynecology
Piperazines - pharmacology
preclinical drug evaluations
Pregnancy
Probability
Purines - pharmacology
Random Allocation
Risk Factors
Sensitivity and Specificity
Sildenafil Citrate
Sulfones - pharmacology
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Summary:Objective Our goal was to determine whether sildenafil increased fetal weight and favored fetal tolerance to induced asphyxia at birth in guinea pigs. Study Design Twenty guinea pigs were randomly allocated to placebo (n = 10) or sildenafil 50 μg/kg (n = 5) or 500 μg/kg (n = 5), starting from day 35 of gestation to delivery. Fetuses were delivered by cesarean section. Fetal asphyxia was induced by clamping the umbilical cord at birth for 5 minutes. Results Sildenafil protected the pups against induced asphyxia at birth in a dose-dependent manner (eg, partial pressure (tension) of carbon dioxide levels were 75.9 ± 19.3, 66.9 ± 18.8, and 54.8 ± 13.0 in the control and low- and high-dose sildenafil groups, respectively). The high-dose sildenafil group of piglets gained 1.5 times more body weight. Conclusion In guinea pigs, low doses of sildenafil administered from day 35 to the end of gestation favored fetal tolerability to induced intrapartum asphyxia. High doses of sildenafil increased fetal weight.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2007.06.068