Impact of Patent Ductus Arteriosus and Subsequent Therapy With Indomethacin on Cerebral Oxygenation in Preterm Infants

A hemodynamically important patent ductus arteriosus is a common problem in the first week of life in the preterm infant. Although patent ductus arteriosus induces alterations in organ perfusion, scarce information is available of the impact of patent ductus arteriosus and its subsequent treatment o...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2008-01, Vol.121 (1), p.142-147
Main Authors: Lemmers, Petra M. A, Toet, Mona C, van Bel, Frank
Format: Article
Language:English
Subjects:
Babies
Biological and medical sciences
Blood Gas Analysis
Brain
Cardiac Surgical Procedures - methods
Care and treatment
Case-Control Studies
Cerebral circulation
Cerebrovascular Circulation - drug effects
Demographic aspects
Dosage and administration
Dose-Response Relationship, Drug
Drug Administration Schedule
Ductus Arteriosus, Patent - diagnostic imaging
Ductus Arteriosus, Patent - mortality
Ductus Arteriosus, Patent - therapy
Echocardiography, Doppler
Female
Follow-Up Studies
General aspects
Hemodynamics - drug effects
Hemodynamics - physiology
Humans
Indomethacin
Indomethacin - administration & dosage
Infant, Newborn
Infant, Premature
Infants (Premature)
Infusions, Intravenous
Intensive Care Units, Neonatal
Male
Medical sciences
Neonatal care
Neurology
Oxygen Consumption - drug effects
Oxygen Consumption - physiology
Patent ductus arteriosus
Pediatrics
Physiological aspects
Premature infants
Probability
Prospective Studies
Reference Values
Risk Factors
Spectrum analysis
Statistics, Nonparametric
Survival Rate
Treatment Outcome
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Description
Summary:A hemodynamically important patent ductus arteriosus is a common problem in the first week of life in the preterm infant. Although patent ductus arteriosus induces alterations in organ perfusion, scarce information is available of the impact of patent ductus arteriosus and its subsequent treatment on the oxygen supply and oxygen extraction of the brain. We investigated the impact of patent ductus arteriosus and its treatment with indomethacin on regional cerebral oxygen saturation and fractional tissue oxygen extraction by using near-infrared spectroscopy. Twenty infants with patent ductus arteriosus (gestational age:
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2007-0925