An unusual clinical presentation of a rare tumor of the thyroid gland: report on one case of leiomyosarcoma and review of literature

Abstract Primary muscle tumors of the thyroid gland are exceedingly rare. We report on the case of a patient with primary leiomyosarcoma of the thyroid gland and review the literature. An 83-year-old woman complaining of neuropathic pain in her left arm and enlargement of her anterior neck underwent...

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Bibliographic Details
Published in:Annals of diagnostic pathology 2008-02, Vol.12 (1), p.50-56
Main Authors: Just, Pierre-Alexandre, Guillevin, Rémy, MD, Capron, Frédérique, MD, PHD, Le Charpentier, Monique, MD, Le Naour, Gilles, Menegaux, Fabrice, MD, PHD, Leenhardt, Laurence, MD, Simon, Jean-Marc, MD, Hoang, Catherine, MD
Format: Article
Language:English
Subjects:
Actin Cytoskeleton - ultrastructure
Actins - analysis
Aged, 80 and over
Fatal Outcome
Female
Humans
Immunohistochemistry
Leiomyoma
Leiomyosarcoma
Leiomyosarcoma - chemistry
Leiomyosarcoma - secondary
Leiomyosarcoma - surgery
Magnetic Resonance Imaging
Microscopy, Electron, Transmission
Pathology
Rhabdomyosarcoma
Thyroid gland
Thyroid Gland - pathology
Thyroid Neoplasms - chemistry
Thyroid Neoplasms - pathology
Thyroid Neoplasms - surgery
Vimentin - analysis
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Summary:Abstract Primary muscle tumors of the thyroid gland are exceedingly rare. We report on the case of a patient with primary leiomyosarcoma of the thyroid gland and review the literature. An 83-year-old woman complaining of neuropathic pain in her left arm and enlargement of her anterior neck underwent multiple surgical biopsies of the thyroid gland. The tumor was composed of interlacing fascicles of spindle-shaped cells that expressed smooth muscle actin and vimentin but were negative for cytokeratins and thyroglobulin. Ultrastructurally, bundles of myofilaments were present. Magnetic resonance imaging showed a thyroid tumor that directly extended to the adjacent vertebra with an associated pachymeningitis. The patient died 2 months after surgery. The diagnosis of primary leiomyosarcoma of the thyroid gland is difficult and requires numerous clinical, radiologic, and pathologic data. To our knowledge, this case is the first one with such a locoregional extension.
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2006.06.006