Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia

Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and nine adult ALL cases. Four genes (p15, p16, RARβ, FHIT) had methylation in both diseases, four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two genes (APC, RIZ) demonstrated methyla...

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Bibliographic Details
Published in:Leukemia research 2006, Vol.30 (1), p.98-102
Main Authors: Yang, Yang, Takeuchi, Seisho, Hofmann, Wolf K., Ikezoe, Takayuki, van Dongen, Jacques J.M., Szczepański, Tomasz, Bartram, Claus R., Yoshino, Norihide, Taguchi, Hirokuni, Koeffler, H. Phillip
Format: Article
Language:English
Subjects:
Adolescent
Adult
ALL
Child
Child, Preschool
CpG Islands
DNA Methylation
Female
Humans
Male
Methylation
Middle Aged
Multiple genes
Neoplasm Proteins - genetics
Neoplasm Proteins - metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism
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Summary:Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and nine adult ALL cases. Four genes (p15, p16, RARβ, FHIT) had methylation in both diseases, four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RARβ was more frequent in adult ALL than that in childhood ALL ( p = 0.01). The number of patients with methylation of multiple genes was higher in adult ALL than that in childhood ALL ( p = 0.006). Moreover, overall frequency of methylation was higher in adult ALL than that in childhood ALL ( p = 0.01).
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2005.06.002