A case of primary gastric small cell carcinoma with a rare pattern of lymph node metastasis

We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The path...

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Bibliographic Details
Published in:International journal of gastrointestinal cancer 2005, Vol.36 (2), p.99-104
Main Authors: Takeuchi, Hiroya, Futamata, Ken, Maeshima, Arafumi, Hirose, Shigemichi, Shimada, Atsushi, Kawaguchi, Yoshiki, Tokuyama, Jo, Osumi, Koji, Kishi, Shinya, Hojo, Takashi, Kim, Shiei, Wada, Norihito, Oishi, Takashi, Isobe, Yoh, Ikeuchi, Shunji, Kubochi, Kiyoshi, Matsumoto, Sumio
Format: Article
Language:English
Subjects:
Carcinoma, Small Cell - immunology
Carcinoma, Small Cell - pathology
Carcinoma, Small Cell - surgery
Fatal Outcome
Humans
Immunohistochemistry
Lymph Nodes - pathology
Lymph Nodes - surgery
Lymphatic Metastasis
Male
Middle Aged
Stomach Neoplasms - immunology
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
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Summary:We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC.
ISSN:1537-3649
1537-3649
DOI:10.1385/IJGC:36:2:99