Artificial Device for Extracorporeal Blood Oxygenation in Rats

:  Blood oxygenation devices are an essential component of any cardiopulomonary bypass circuit in various species of laboratory animals. When using larger animals like dogs or pigs, the human and pediatric blood oxygenators could be easily used, but the disadvantage of these species is the scarcity...

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Bibliographic Details
Published in:Artificial organs 2008-01, Vol.32 (1), p.66-70
Main Authors: Ordodi, Valentin Laurentiu, Paunescu, Virgil, Ionac, Mihai, Sandesc, Dorel, Mic, Ani Aurora, Tatu, Calin Adrian, Mic, Felix Aurel
Format: Article
Language:English
Subjects:
Animals
Blood oxygenation
Cardiopulmonary Bypass - instrumentation
Lung artificial device
Male
Oxygenator rat
Oxygenators
Rats - surgery
Rats, Sprague-Dawley
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Summary::  Blood oxygenation devices are an essential component of any cardiopulomonary bypass circuit in various species of laboratory animals. When using larger animals like dogs or pigs, the human and pediatric blood oxygenators could be easily used, but the disadvantage of these species is the scarcity of biochemical and genetic assays for experimental follow‐up. However, small rodents like rats have plenty of biochemical assays, but their size requires special oxygenators adapted for their small blood volume and often primed with blood of another animal or other physiological solution. We showed the new design of a blood oxygenator with direct blood–gas contact in an open circuit, specially designed for rats in which the blood oxygenation takes place in a slowly rotating plastic tube with blood spread onto its inner walls in a thin layer. The oxygenator is simple and efficient, does not require priming with the blood of another rat, has a small dead volume, is reusable, and easy to clean and sterilize.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2007.00461.x