Loading…
Structural and Functional Remodeling of the Left Atrium : Clinical and Therapeutic Implications for Atrial Fibrillation
Left atrial (LA) structural and functional remodeling reflects a spectrum of pathophysiological changes that have occurred in response to specific stressors. These changes include alterations at the levels of ionic channels, cellular energy balance, neurohormonal expression, inflammatory response, a...
Saved in:
| Published in: | Journal of the American College of Cardiology 2008, Vol.51 (1), p.1-11 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | 11 |
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 51 |
| creator | CASACLANG-VERZOSA, Grace GERSH, Bernard J TSANG, Teresa S. M |
| description | Left atrial (LA) structural and functional remodeling reflects a spectrum of pathophysiological changes that have occurred in response to specific stressors. These changes include alterations at the levels of ionic channels, cellular energy balance, neurohormonal expression, inflammatory response, and physiologic adaptations. There is convincing evidence demonstrating an important pathophysiological association between LA remodeling and atrial fibrillation (AF). Measures that will prevent, attenuate, or halt these processes of LA remodeling may have a major public health impact with respect to the epidemic of AF. In this review, we describe the mechanisms involved in LA remodeling and highlight the existing and potential therapeutic options for its reversal, and implications for AF development. |
| doi_str_mv | 10.1016/j.jacc.2007.09.026 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70182317</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70182317</sourcerecordid><originalsourceid>FETCH-LOGICAL-h214t-31b0fc1e1f0557c4b3dd888dcd2b593d9e8f40cdff8c80e562e2041c8eb447463</originalsourceid><addsrcrecordid>eNpdkFtr3DAQhUVoaLZp_0AegqC0b3ZnbMuS8haWbhtYCLTps7F1yWrxZaMLIf--arKhkKdhON85MxxCLhBKBGy_7ct9r1RZAfASZAlVe0JWyJgoaib5O7ICXrMCQfIz8iGEPQC0AuV7coYCeQOVXJHH39EnFZPvR9rPmm7SrKJb5rz-MtOizejme7pYGneGbo2N9Dp6lyZ6RddZcurou9sZ3x9Mik7Rm-kwZuFfTKB28c-WzG3c4N04Pgsfyantx2A-Hec5-bP5frf-WWxvf9ysr7fFrsImFjUOYBUatMAYV81Qay2E0EpXA5O1lkbYBpS2VigBhrWVqaBBJczQNLxp63Py9SX34JeHZELsJheUyV_MZkmh44CiqpFn8PMbcL8kn3sIHTJoUbaCY6Yuj1QaJqO7g3dT75-610Iz8OUI9CF3Y30_Kxf-c1IKzPfqv_O8hmY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506196871</pqid></control><display><type>article</type><title>Structural and Functional Remodeling of the Left Atrium : Clinical and Therapeutic Implications for Atrial Fibrillation</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>CASACLANG-VERZOSA, Grace ; GERSH, Bernard J ; TSANG, Teresa S. M</creator><creatorcontrib>CASACLANG-VERZOSA, Grace ; GERSH, Bernard J ; TSANG, Teresa S. M</creatorcontrib><description>Left atrial (LA) structural and functional remodeling reflects a spectrum of pathophysiological changes that have occurred in response to specific stressors. These changes include alterations at the levels of ionic channels, cellular energy balance, neurohormonal expression, inflammatory response, and physiologic adaptations. There is convincing evidence demonstrating an important pathophysiological association between LA remodeling and atrial fibrillation (AF). Measures that will prevent, attenuate, or halt these processes of LA remodeling may have a major public health impact with respect to the epidemic of AF. In this review, we describe the mechanisms involved in LA remodeling and highlight the existing and potential therapeutic options for its reversal, and implications for AF development.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2007.09.026</identifier><identifier>PMID: 18174029</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Aging ; Angiotensin II Type 1 Receptor Blockers - pharmacology ; Angiotensin II Type 1 Receptor Blockers - therapeutic use ; Angiotensin-Converting Enzyme Inhibitors - pharmacology ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Antifibrinolytic Agents - pharmacology ; Antifibrinolytic Agents - therapeutic use ; Apoptosis ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - therapy ; Biological and medical sciences ; Cardiac arrhythmia ; Cardiac dysrhythmias ; Cardiology ; Cardiology. Vascular system ; Catheter Ablation ; Clinical Trials as Topic ; Confidence intervals ; Drug therapy ; Electric Countershock ; Electrophysiologic Techniques, Cardiac ; Heart ; Heart Atria - drug effects ; Heart Atria - metabolism ; Heart Atria - physiopathology ; Heart attacks ; Heart failure ; Humans ; Hypertension ; Ischemia ; Medical sciences ; Mortality ; Studies</subject><ispartof>Journal of the American College of Cardiology, 2008, Vol.51 (1), p.1-11</ispartof><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 1, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19981231$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18174029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CASACLANG-VERZOSA, Grace</creatorcontrib><creatorcontrib>GERSH, Bernard J</creatorcontrib><creatorcontrib>TSANG, Teresa S. M</creatorcontrib><title>Structural and Functional Remodeling of the Left Atrium : Clinical and Therapeutic Implications for Atrial Fibrillation</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Left atrial (LA) structural and functional remodeling reflects a spectrum of pathophysiological changes that have occurred in response to specific stressors. These changes include alterations at the levels of ionic channels, cellular energy balance, neurohormonal expression, inflammatory response, and physiologic adaptations. There is convincing evidence demonstrating an important pathophysiological association between LA remodeling and atrial fibrillation (AF). Measures that will prevent, attenuate, or halt these processes of LA remodeling may have a major public health impact with respect to the epidemic of AF. In this review, we describe the mechanisms involved in LA remodeling and highlight the existing and potential therapeutic options for its reversal, and implications for AF development.</description><subject>Aging</subject><subject>Angiotensin II Type 1 Receptor Blockers - pharmacology</subject><subject>Angiotensin II Type 1 Receptor Blockers - therapeutic use</subject><subject>Angiotensin-Converting Enzyme Inhibitors - pharmacology</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Antifibrinolytic Agents - pharmacology</subject><subject>Antifibrinolytic Agents - therapeutic use</subject><subject>Apoptosis</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - therapy</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Catheter Ablation</subject><subject>Clinical Trials as Topic</subject><subject>Confidence intervals</subject><subject>Drug therapy</subject><subject>Electric Countershock</subject><subject>Electrophysiologic Techniques, Cardiac</subject><subject>Heart</subject><subject>Heart Atria - drug effects</subject><subject>Heart Atria - metabolism</subject><subject>Heart Atria - physiopathology</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Ischemia</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Studies</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNpdkFtr3DAQhUVoaLZp_0AegqC0b3ZnbMuS8haWbhtYCLTps7F1yWrxZaMLIf--arKhkKdhON85MxxCLhBKBGy_7ct9r1RZAfASZAlVe0JWyJgoaib5O7ICXrMCQfIz8iGEPQC0AuV7coYCeQOVXJHH39EnFZPvR9rPmm7SrKJb5rz-MtOizejme7pYGneGbo2N9Dp6lyZ6RddZcurou9sZ3x9Mik7Rm-kwZuFfTKB28c-WzG3c4N04Pgsfyantx2A-Hec5-bP5frf-WWxvf9ysr7fFrsImFjUOYBUatMAYV81Qay2E0EpXA5O1lkbYBpS2VigBhrWVqaBBJczQNLxp63Py9SX34JeHZELsJheUyV_MZkmh44CiqpFn8PMbcL8kn3sIHTJoUbaCY6Yuj1QaJqO7g3dT75-610Iz8OUI9CF3Y30_Kxf-c1IKzPfqv_O8hmY</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>CASACLANG-VERZOSA, Grace</creator><creator>GERSH, Bernard J</creator><creator>TSANG, Teresa S. M</creator><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Structural and Functional Remodeling of the Left Atrium : Clinical and Therapeutic Implications for Atrial Fibrillation</title><author>CASACLANG-VERZOSA, Grace ; GERSH, Bernard J ; TSANG, Teresa S. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h214t-31b0fc1e1f0557c4b3dd888dcd2b593d9e8f40cdff8c80e562e2041c8eb447463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aging</topic><topic>Angiotensin II Type 1 Receptor Blockers - pharmacology</topic><topic>Angiotensin II Type 1 Receptor Blockers - therapeutic use</topic><topic>Angiotensin-Converting Enzyme Inhibitors - pharmacology</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Antifibrinolytic Agents - pharmacology</topic><topic>Antifibrinolytic Agents - therapeutic use</topic><topic>Apoptosis</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - therapy</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Catheter Ablation</topic><topic>Clinical Trials as Topic</topic><topic>Confidence intervals</topic><topic>Drug therapy</topic><topic>Electric Countershock</topic><topic>Electrophysiologic Techniques, Cardiac</topic><topic>Heart</topic><topic>Heart Atria - drug effects</topic><topic>Heart Atria - metabolism</topic><topic>Heart Atria - physiopathology</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Ischemia</topic><topic>Medical sciences</topic><topic>Mortality</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CASACLANG-VERZOSA, Grace</creatorcontrib><creatorcontrib>GERSH, Bernard J</creatorcontrib><creatorcontrib>TSANG, Teresa S. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CASACLANG-VERZOSA, Grace</au><au>GERSH, Bernard J</au><au>TSANG, Teresa S. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural and Functional Remodeling of the Left Atrium : Clinical and Therapeutic Implications for Atrial Fibrillation</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2008</date><risdate>2008</risdate><volume>51</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Left atrial (LA) structural and functional remodeling reflects a spectrum of pathophysiological changes that have occurred in response to specific stressors. These changes include alterations at the levels of ionic channels, cellular energy balance, neurohormonal expression, inflammatory response, and physiologic adaptations. There is convincing evidence demonstrating an important pathophysiological association between LA remodeling and atrial fibrillation (AF). Measures that will prevent, attenuate, or halt these processes of LA remodeling may have a major public health impact with respect to the epidemic of AF. In this review, we describe the mechanisms involved in LA remodeling and highlight the existing and potential therapeutic options for its reversal, and implications for AF development.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>18174029</pmid><doi>10.1016/j.jacc.2007.09.026</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2008, Vol.51 (1), p.1-11 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70182317 |
| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Aging Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 1 Receptor Blockers - therapeutic use Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antifibrinolytic Agents - pharmacology Antifibrinolytic Agents - therapeutic use Apoptosis Atrial Fibrillation - physiopathology Atrial Fibrillation - therapy Biological and medical sciences Cardiac arrhythmia Cardiac dysrhythmias Cardiology Cardiology. Vascular system Catheter Ablation Clinical Trials as Topic Confidence intervals Drug therapy Electric Countershock Electrophysiologic Techniques, Cardiac Heart Heart Atria - drug effects Heart Atria - metabolism Heart Atria - physiopathology Heart attacks Heart failure Humans Hypertension Ischemia Medical sciences Mortality Studies |
| title | Structural and Functional Remodeling of the Left Atrium : Clinical and Therapeutic Implications for Atrial Fibrillation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T21%3A17%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Structural%20and%20Functional%20Remodeling%20of%20the%20Left%20Atrium%20:%20Clinical%20and%20Therapeutic%20Implications%20for%20Atrial%20Fibrillation&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=CASACLANG-VERZOSA,%20Grace&rft.date=2008&rft.volume=51&rft.issue=1&rft.spage=1&rft.epage=11&rft.pages=1-11&rft.issn=0735-1097&rft.eissn=1558-3597&rft.coden=JACCDI&rft_id=info:doi/10.1016/j.jacc.2007.09.026&rft_dat=%3Cproquest_pubme%3E70182317%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-h214t-31b0fc1e1f0557c4b3dd888dcd2b593d9e8f40cdff8c80e562e2041c8eb447463%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1506196871&rft_id=info:pmid/18174029&rfr_iscdi=true |