Effect of X-Radiation on Lipid Peroxidation and Antioxidant Systems in Rats Treated with Saponin-containing Compounds

• Published in: Photochemistry and photobiology 2008-01, Vol.84 (1), p.236-242
• Main Authors: Yalinkilic, Omer, Enginar, Huseyin
• Format: Article
• Language: English
• Subjects: Amino acids; Animals; Antioxidants; Antioxidants - metabolism; Laboratory animals; Lipid Peroxidation - drug effects; Lipid Peroxidation - radiation effects; Lipids; Male; Medicago sativa; Nutrition; Plant Extracts - chemistry; Plant Extracts - pharmacology; Radiation therapy; Rats; Rats, Wistar; Rodents; Sapindus - chemistry; Saponins - pharmacology; Seeds - chemistry; Spinacia oleracea; Vitamin A; Vitamin B
• ISSN: 0031-8655; 1751-1097
• DOI: 10.1111/j.1751-1097.2007.00240.x

The aim of this study was to investigate the effect of three saponin‐containing plant species extracts (Aesculuc hippocastanum L. seed extract [AHE], Medicago sativa L. extract [MSE] and Spinacia oleracea L. extract [SOE]) on lipid peroxidation and on antioxidant systems in rats exposed to X‐rays (XR). The rats were divided into three categories. The first category served as controls and received only a standard diet. The second category served as the radiation group and received 5 and 10 Gy XR dose. The third category (XR+extract‐treated) received plant extracts (25.0 or 50.0 mg kg−1 live weight) and 5 or 10 Gy XR dose. Blood samples were analyzed for their content of malondialdehyde (MDA), reduced glutathione (GSH), plasma vitamin C, β‐carotene and retinol. In animals receiving XR, the plasma MDA (P