The effect of surface modification of a porous TiO2/perlite composite on the ingrowth of bone tissue in vivo

The porous TiO2/perlite composite Ecopore is a synthetic biomaterial with possible clinical application in bone substitution. In our previous work, we demonstrated that surface modification of Ecopore with fibronectin (FN) enhanced spreading and growth of human osteoblasts in vitro. In the present s...

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Bibliographic Details
Published in:Biomaterials 2006-03, Vol.27 (8), p.1270-1276
Main Authors: Erli, Hans-Josef, Rüger, Matthias, Ragoss, Christian, Jahnen-Dechent, Willi, Hollander, Dirk A, Paar, Othmar, von Walter, Matthias
Format: Article
Language:English
Subjects:
Animals
Bone Substitutes - chemistry
Female
Femur - cytology
Femur - injuries
Femur - surgery
Fracture Healing - physiology
Osseointegration - drug effects
Rabbits
Silicon Dioxide
Surface Properties
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Summary:The porous TiO2/perlite composite Ecopore is a synthetic biomaterial with possible clinical application in bone substitution. In our previous work, we demonstrated that surface modification of Ecopore with fibronectin (FN) enhanced spreading and growth of human osteoblasts in vitro. In the present study, we implanted untreated, alkaline-etched and FN-coated Ecopore cylinders into critical size defects of rabbit femora and applied pulsed polychrome sequence staining. After 6 weeks, sections of the implants were investigated via conventional and fluorescence microscopy. A partial ingrowth of bone matrix into the pore system of the Ecopore implants was observed. At the contact zones, the bone appeared to be directly connected to the implant without detectable gaps. Defect healing was complete within 6 weeks, while fibrous tissue generation or inflammation were absent in the implant modification groups, demonstrating basic Ecopore biocompatibility. The mean bone apposition rates within the implant cross-section were 4.1+/-0.6 microm/day (p
ISSN:0142-9612
DOI:10.1016/j.biomaterials.2005.08.001