Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells

MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth...

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Bibliographic Details
Published in:The Journal of biological chemistry 2008-01, Vol.283 (2), p.1026-1033
Main Authors: Frankel, Lisa B., Christoffersen, Nanna R., Jacobsen, Anders, Lindow, Morten, Krogh, Anders, Lund, Anders H.
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis Regulatory Proteins - genetics
Apoptosis Regulatory Proteins - physiology
Base Sequence
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cell Division
Cell Line, Tumor
Female
Humans
Kinetics
MicroRNAs - genetics
RNA, Neoplasm - genetics
RNA-Binding Proteins - genetics
RNA-Binding Proteins - physiology
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Summary:MicroRNAs are emerging as important regulators of cancer-related processes. The miR-21 microRNA is overexpressed in a wide variety of cancers and has been causally linked to cellular proliferation, apoptosis, and migration. Inhibition of mir-21 in MCF-7 breast cancer cells causes reduced cell growth. Using array expression analysis of MCF-7 cells depleted of miR-21, we have identified mRNA targets of mir-21 and have shown a link between miR-21 and the p53 tumor suppressor protein. We furthermore found that the tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and demonstrated that PDCD4 is a functionally important target for miR-21 in breast cancer cells.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.M707224200