GATA-1: One protein, many partners

GATA-1, the founding member of the GATA transcription factor family, is essential for cell maturation and differentiation within the erythroid and megakaryocytic lineages. GATA-1 regulates the expression of many genes within these lineages and its functionality depends upon its ability to bind both...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2006, Vol.38 (1), p.6-11
Main Authors: Lowry, Jason A., Mackay, Joel P.
Format: Article
Language:English
Subjects:
Anemia - genetics
Anemia - metabolism
Animals
Cell Differentiation - physiology
Cell Movement - physiology
Erythropoiesis - physiology
Factor
Finger
GATA1 Transcription Factor - chemistry
GATA1 Transcription Factor - genetics
GATA1 Transcription Factor - metabolism
Hematopoiesis
Humans
Protein Structure, Tertiary
Structure-Activity Relationship
Thrombocytopenia - genetics
Thrombocytopenia - metabolism
Thrombopoiesis - physiology
Transcription
Zinc
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Description
Summary:GATA-1, the founding member of the GATA transcription factor family, is essential for cell maturation and differentiation within the erythroid and megakaryocytic lineages. GATA-1 regulates the expression of many genes within these lineages and its functionality depends upon its ability to bind both DNA and protein partners. Disruption of either of these functions causes severe hematopoietic dysfunction and results in blood disorders, such as thrombocytopenia and anemia. Within this review, we will focus on the structural aspects of GATA-1 with regard to interactions with its many partners and the identification of several mutations that disrupt these interactions.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2005.06.017