CD22 Regulates Time Course of Both B Cell Division and Antibody Response

Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study,...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2008-01, Vol.180 (2), p.907-913
Main Authors: Onodera, Taishi, Poe, Jonathan C, Tedder, Thomas F, Tsubata, Takeshi
Format: Article
Language:English
Subjects:
Animals
Antibody Formation - genetics
Antigens - immunology
Antigens - pharmacology
B-Lymphocytes - cytology
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
Cell Division - genetics
Lymphocyte Activation - genetics
Mice
Mice, Mutant Strains
Plasma Cells - immunology
Sialic Acid Binding Ig-like Lectin 2 - genetics
Sialic Acid Binding Ig-like Lectin 2 - physiology
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Summary:Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.180.2.907