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CD22 Regulates Time Course of Both B Cell Division and Antibody Response

Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study,...

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Published in:	The Journal of immunology (1950) 2008-01, Vol.180 (2), p.907-913
Main Authors:	Onodera, Taishi, Poe, Jonathan C, Tedder, Thomas F, Tsubata, Takeshi
Format:	Article
Language:	English
Subjects:	Animals Antibody Formation - genetics Antigens - immunology Antigens - pharmacology B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Cell Division - genetics Lymphocyte Activation - genetics Mice Mice, Mutant Strains Plasma Cells - immunology Sialic Acid Binding Ig-like Lectin 2 - genetics Sialic Acid Binding Ig-like Lectin 2 - physiology
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creator	Onodera, Taishi Poe, Jonathan C Tedder, Thomas F Tsubata, Takeshi
description	Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."
doi_str_mv	10.4049/jimmunol.180.2.907
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subjects	Animals Antibody Formation - genetics Antigens - immunology Antigens - pharmacology B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Cell Division - genetics Lymphocyte Activation - genetics Mice Mice, Mutant Strains Plasma Cells - immunology Sialic Acid Binding Ig-like Lectin 2 - genetics Sialic Acid Binding Ig-like Lectin 2 - physiology
title	CD22 Regulates Time Course of Both B Cell Division and Antibody Response
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