Favorable Entropy of Aromatic Clusters in Thermophilic Proteins

Aromatic clusters, found with increased frequency in a set of thermophilic proteins, confer an entropic advantage over mesophilic analogues through introduction of large-amplitude oscillations; this is a source of improved free energy at high temperatures.

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Bibliographic Details
Published in:The journal of physical chemistry. B 2005-09, Vol.109 (38), p.18184-18188
Main Authors: Trebbi, Bruno, Dehez, Francois, Fowler, Patrick W, Zerbetto, Francesco
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acids, Aromatic - chemistry
Calorimetry
Entropy
Enzymes - chemistry
Proteins - chemistry
Thermodynamics
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Description
Summary:Aromatic clusters, found with increased frequency in a set of thermophilic proteins, confer an entropic advantage over mesophilic analogues through introduction of large-amplitude oscillations; this is a source of improved free energy at high temperatures.
ISSN:1520-6106
1520-5207
DOI:10.1021/jp052333u