Rapid regression of extensive retinovitreal neovascularization secondary to branch retinal vein occlusion after a single intravitreal injection of bevacizumab

To report the rapid regression of extensive retinovitreal neovascularization following the administration of a single dose of intravitreal bevacizumab. A 60-year-old woman presented with recurrent vitreous hemorrhage originating from active retinovitreal neovascularization secondary to branch retina...

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Bibliographic Details
Published in:International ophthalmology 2005-10, Vol.26 (4-5), p.191-193
Main Authors: Ahmadieh, Hamid, Moradian, Siamak, Malihi, Mohsen
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - administration & dosage
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal, Humanized
Bevacizumab
Disease Progression
Female
Fluorescein Angiography
Follow-Up Studies
Fundus Oculi
Humans
Injections
Middle Aged
Retinal Neovascularization - drug therapy
Retinal Neovascularization - etiology
Retinal Vein Occlusion - complications
Retinal Vein Occlusion - pathology
Tomography, Optical Coherence
Vascular Endothelial Growth Factor A
Vitreous Body - blood supply
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Summary:To report the rapid regression of extensive retinovitreal neovascularization following the administration of a single dose of intravitreal bevacizumab. A 60-year-old woman presented with recurrent vitreous hemorrhage originating from active retinovitreal neovascularization secondary to branch retinal vein occlusion. The neovascular tissue remained active despite multiple sessions of laser therapy. Intravitreal injection of 1.25 mg bevacizumab was performed. Rapid regression of the retinovitreal neovascularization, a marked reduction in retinal vein engorgement, and visual improvement was observed 1 week after the intervention Intravitreal bevacizumab can result in the rapid and dramatic regression of retinovitreal neovascularization refractory to previous laser photocoagulation.
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-007-9036-y