HFE-Codon 63/282 (H63D/C282Y) Gene Variants in Mexican Mestizos Are Not Risk Factors for Leukemia

In some Caucasian populations it has been found that the C282Y hemochromatosis (HFE) gene mutation is a risk factor for the development of leukemia and other malignancies. In a group of 50 Mexican mestizo patients and 153 normal controls, the HFE gene mutations H63D and C282Y were studied by means o...

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Bibliographic Details
Published in:Archives of medical research 2006, Vol.37 (1), p.65-67
Main Authors: Ruiz-Argüelles, Guillermo J., Morales-Toquero, Amelia, Cruz-Domínguez, Grethel, Reyes-Núñez, Virginia, López-Martínez, Briceida, Ruiz-Delgado, Guillermo J., Garcés-Eisele, Javier
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Amino Acid Substitution
Child
Child, Preschool
Codon - genetics
Female
Gene Frequency - genetics
Hemochromatosis
Hemochromatosis Protein
HFE gene
Histocompatibility Antigens Class I - genetics
Humans
Leukemia
Leukemia - genetics
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - genetics
Male
Membrane Proteins - genetics
Mexico
Middle Aged
Mutations
Point Mutation
Risk Factors
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Summary:In some Caucasian populations it has been found that the C282Y hemochromatosis (HFE) gene mutation is a risk factor for the development of leukemia and other malignancies. In a group of 50 Mexican mestizo patients and 153 normal controls, the HFE gene mutations H63D and C282Y were studied by means of ARMS-PCR. In the group of patients with leukemia we found a heterozygote for the C282Y mutation, seven heterozygotes for the H63D mutation, a double heterozygote for the H63D / C282Y mutation and 41 normal homozygotes. These data are not different from those observed in normal controls, where the allele frequencies were 0.062 and 0.013 for the H63D and C282Y HFE gene mutations, respectively. These HFE gene mutations are not risk factors for the development of leukemia in Mexican mestizos.
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2005.04.014