Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa

The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5-18, four novel alkaloids of this class, compounds 1-4, have been isolated, and thei...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2006, Vol.14 (1), p.17-24
Main Authors: AIELLO, Anna, D'ESPOSITO, Monica, FATTORUSSO, Ernesto, MENNA, Marialuisa, MÜLLER, Werner E. G, PEROVIC-OTTSTADT, Sanja, SCHRÖDER, Heinz C
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Biological and medical sciences
Calcium - metabolism
Cell Line
Chromatography, Thin Layer
Excitatory Amino Acid Antagonists - pharmacology
General pharmacology
Glutamic Acid - drug effects
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Neurons - drug effects
Neurons - metabolism
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Porifera - chemistry
Pyrroles - chemistry
Pyrroles - isolation & purification
Pyrroles - pharmacology
Quisqualic Acid - pharmacology
Serotonin - pharmacology
Serotonin Antagonists - pharmacology
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Fast Atom Bombardment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5-18, four novel alkaloids of this class, compounds 1-4, have been isolated, and their structures established through spectroscopic methods. Compounds 1-4 were found to display neuroprotective activity against the agonists serotonin and glutamate in vitro.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2005.07.057